Table 2.
Significant associations of gene expression and logGI50 of Indian Natural Products in the NCI-60 cell line panel
| NSC | Gene | Spearman ρ | Original p value | FDR adjusted p value | Dendrogram subtree | Active molecule |
|---|---|---|---|---|---|---|
| 328426 | MYB | -0.66 | 1.7e-08 | 0.004 | Subtree 1 | Phyllanthoside |
| 328426 | BEND7 | 0.65 | 2.8e-08 | 0.005 | Subtree 1 | Phyllanthoside |
| 308606 | ZBTB33 | -0.67 | 1.0e-07 | 0.012 | Subtree 1 | Cucurbitacin D |
| 328426 | NHS | 0.62 | 2.0e-07 | 0.014 | Subtree 1 | Phyllanthoside |
| 328426 | WWC1 | 0.61 | 3.0e-07 | 0.019 | Subtree 1 | Phyllanthoside |
| 94743 | TRMT112 | 0.65 | 4.0e-07 | 0.022 | Subtree 1 | Cucurbitacin A |
| 328426 | RBMS2 | 0.60 | 5.0e-07 | 0.022 | Subtree 1 | Phyllanthoside |
| 342443 | EHD2 | 0.66 | 6.0e-07 | 0.025 | Subtree 1 | S3’-desacetyl-phyllanthoside |
| 328426 | PROSER2 | 0.60 | 8.0e-07 | 0.027 | Subtree 1 | Phyllanthoside |
| 328426 | SMAP2 | -0.60 | 8.0e-07 | 0.027 | Subtree 1 | Phyllanthoside |
| 328426 | BAGE | -0.59 | 8.0e-07 | 0.027 | Subtree 1 | Phyllanthoside |
| 328426 | C6orf89 | -0.59 | 9.0e-07 | 0.027 | Subtree 1 | Phyllanthoside |
| 328426 | EGFR | 0.59 | 1.0e-06 | 0.027 | Subtree 1 | Phyllanthoside |
| 328426 | PDLIM1 | 0.59 | 1.0e-06 | 0.027 | Subtree 1 | Phyllanthoside |
| 94743 | ZNF48 | 0.63 | 1.0e-06 | 0.027 | Subtree 1 | Cucurbitacin A |
| 328426 | CNPPD1 | -0.59 | 1.1e-06 | 0.029 | Subtree 1 | Phyllanthoside |
| 342443 | CLMP | 0.65 | 1.1e-06 | 0.029 | Subtree 1 | S3’-desacetyl-phyllanthoside |
| 143925 | ATP1A1 | 0.59 | 1.2e-06 | 0.030 | Subtree 1 | Pekilocerin A |
| 342443 | ADAM9 | 0.64 | 1.4e-06 | 0.031 | Subtree 1 | S3’-desacetyl-phyllanthoside |
| 328426 | MON1A | -0.58 | 1.4e-06 | 0.031 | Subtree 1 | Phyllanthoside |
| 328426 | ZNF319 | 0.58 | 1.6e-06 | 0.033 | Subtree 1 | Phyllanthoside |
| 328426 | HKDC1 | 0.58 | 1.8e-06 | 0.036 | Subtree 1 | Phyllanthoside |
| 342443 | CD151 | 0.64 | 2.0e-06 | 0.037 | Subtree 1 | S3’-desacetyl-phyllanthoside |
| 328426 | AJUBA | 0.58 | 2.1e-06 | 0.038 | Subtree 1 | Phyllanthoside |
| 112167 | TLN1 | -0.62 | 2.3e-06 | 0.040 | Subtree 1 | Elatericin B |
| 328426 | HESX1 | -0.57 | 2.4e-06 | 0.040 | Subtree 1 | Phyllanthoside |
| 328426 | MMP24 | 0.57 | 2.5e-06 | 0.042 | Subtree 1 | Phyllanthoside |
| 328426 | TJP1 | 0.57 | 2.7e-06 | 0.043 | Subtree 1 | Phyllanthoside |
| 328426 | TNFRSF12A | 0.57 | 2.7e-06 | 0.043 | Subtree 1 | Phyllanthoside |
| 342443 | ZFP36L1 | 0.63 | 2.9e-06 | 0.043 | Subtree 1 | S3’-desacetyl-phyllanthoside |
| 342443 | NNMT | 0.63 | 3.0e-06 | 0.043 | Subtree 1 | S3’-desacetyl-phyllanthoside |
| 328426 | BIN1 | 0.57 | 3.0e-06 | 0.043 | Subtree 1 | Phyllanthoside |
| 342443 | MTCL1 | 0.63 | 3.1e-06 | 0.043 | Subtree 1 | S3’-desacetyl-phyllanthoside |
| 342443 | TNFRSF1A | 0.62 | 3.8e-06 | 0.046 | Subtree 1 | S3’-desacetyl-phyllanthoside |
| 342443 | LOC101241902 | 0.62 | 3.8e-06 | 0.046 | Subtree 1 | S3’-desacetyl-phyllanthoside |
| 328426 | GOLGA6L5P | 0.56 | 3.9e-06 | 0.046 | Subtree 1 | Phyllanthoside |
| 521777 | SLAMF6 | 0.56 | 3.9e-06 | 0.046 | Subtree 1 | Elatericin B |
| 342443 | UCKL1 | -0.62 | 3.9e-06 | 0.046 | Subtree 1 | S3’-desacetyl-phyllanthoside |
| 143925 | ILF2P1 | -0.56 | 4.0e-06 | 0.046 | Subtree 1 | Pekilocerin A |
| 328426 | NUAK2 | 0.56 | 4.0e-06 | 0.046 | Subtree 1 | Phyllanthoside |
| 328426 | PUS3 | -0.56 | 4.1e-06 | 0.046 | Subtree 1 | Phyllanthoside |
| 328426 | C2CD2L | -0.56 | 4.3e-06 | 0.046 | Subtree 1 | Phyllanthoside |
| 342443 | NRP1 | 0.62 | 4.3e-06 | 0.046 | Subtree 1 | S3’-desacetyl-phyllanthoside |
| 328426 | LRRN4 | 0.56 | 4.3e-06 | 0.046 | Subtree 1 | Phyllanthoside |
| 328426 | SLC35F3 | 0.56 | 4.4e-06 | 0.046 | Subtree 1 | Phyllanthoside |
| 328426 | ZNF639 | -0.56 | 4.6e-06 | 0.046 | Subtree 1 | Phyllanthoside |
| 143925 | FNIP1 | 0.56 | 4.7e-06 | 0.046 | Subtree 1 | Pekilocerin A |
| 94743 | ZNF629 | 0.60 | 4.8e-06 | 0.046 | Subtree 1 | Cucurbitacin A |
| 328426 | FRAT2 | -0.56 | 5.6e-06 | 0.048 | Subtree 1 | Phyllanthoside |
| 342443 | NR2F2 | 0.61 | 5.8e-06 | 0.049 | Subtree 1 | S3’-desacetyl-phyllanthoside |
| 342443 | ITGB1 | 0.61 | 5.9e-06 | 0.049 | Subtree 1 | S3’-desacetyl-phyllanthoside |
| 328426 | CLDN1 | 0.56 | 5.9e-06 | 0.049 | Subtree 1 | Phyllanthoside |
| 844 | ZNF823 | 0.65 | 5.0e-07 | 0.022 | Subtree 2 | Nesol |
| 62794 | FOXN4 | -0.62 | 1.2e-06 | 0.030 | Subtree 2 | Beta carotene |
| 327430 | OGFOD2 | -0.64 | 1.7e-06 | 0.035 | Subtree 2 | Resveratrol |
| 90487 | SDHC | 0.57 | 3.6e-06 | 0.046 | Subtree 2 | Lupeol |
| 643160 | LCP1 | -0.62 | 4.0e-06 | 0.046 | Subtree 2 | 3-Bromo-4-dimethylamino-alpha-benzoyl cinnamonitrite |
| 844 | PBX4 | 0.60 | 4.2e-06 | 0.046 | Subtree 2 | Nesol |
| 90487 | PFKFB2 | 0.56 | 5.3e-06 | 0.048 | Subtree 2 | Lupeol |
| 619043 | KIR2DL2 | -0.63 | 5.6e-06 | 0.049 | Subtree 2 | Phyllanthin |
| 236613 | SLC7A11 | 0.79 | 1.0e-13 | 0.000 | Subtree 3 | Plumbagin |
| 32982 | ATAD3B | -0.67 | 1.3e-08 | 0.003 | Subtree 3 | Curcumin |
| 309909 | PDCD11 | -0.66 | 2.3e-08 | 0.005 | Subtree 3 | Nimbolide |
| 32982 | HNRNPR | -0.66 | 3.0e-08 | 0.005 | Subtree 3 | Curcumin |
| 309909 | RPL34P6 | -0.64 | 1.0e-07 | 0.009 | Subtree 3 | Nimbolide |
| 32982 | RPL11 | -0.64 | 1.0e-07 | 0.012 | Subtree 3 | Curcumin |
| 32982 | PNRC2 | -0.64 | 1.0e-07 | 0.012 | Subtree 3 | Curcumin |
| 236613 | HDHD2 | -0.63 | 1.0e-07 | 0.013 | Subtree 3 | Plumbagin |
| 309909 | RPL34 | -0.63 | 1.0e-07 | 0.013 | Subtree 3 | Nimbolide |
| 309909 | HNRNPA1P55 | -0.63 | 2.0e-07 | 0.014 | Subtree 3 | Nimbolide |
| 87868 | NOLC1 | -0.68 | 2.0e-07 | 0.014 | Subtree 3 | Phenethyl mustard oil |
| 87868 | NPM3 | -0.68 | 2.0e-07 | 0.014 | Subtree 3 | Phenethyl mustard oil |
| 236613 | NR2F1 | 0.62 | 2.0e-07 | 0.014 | Subtree 3 | Plumbagin |
| 742021 | ERICH1 | -0.62 | 2.0e-07 | 0.017 | Subtree 3 | Curcumin tri adamantylaminoethylcarbonate |
| 87868 | SRPK1 | -0.67 | 3.0e-07 | 0.018 | Subtree 3 | Phenethyl mustard oil |
| 309909 | RPS10P2 | -0.62 | 3.0e-07 | 0.018 | Subtree 3 | Nimbolide |
| 87868 | RBMXP1 | -0.67 | 3.0e-07 | 0.018 | Subtree 3 | Phenethyl mustard oil |
| 742020 | RPL21P134 | -0.61 | 3.0e-07 | 0.018 | Subtree 3 | Ethoxycurcumin trithiadiazolaminomethylcarbonte |
| 705537 | C5orf15 | -0.63 | 4.0e-07 | 0.022 | Subtree 3 | Daturaolone |
| 742022 | CCDC149 | 0.61 | 4.0e-07 | 0.022 | Subtree 3 | Curcumin tri trithiadiazolaminoethylcarbonate |
| 742020 | RPL13AP3 | -0.61 | 5.0e-07 | 0.022 | Subtree 3 | Ethoxycurcumin trithiadiazolaminomethylcarbonte |
| 87868 | ADAT2 | -0.66 | 5.0e-07 | 0.022 | Subtree 3 | Phenethyl mustard oil |
| 87868 | HIF1A | 0.66 | 5.0e-07 | 0.022 | Subtree 3 | Phenethyl mustard oil |
| 236613 | SLC7A11-AS1 | 0.60 | 5.0e-07 | 0.022 | Subtree 3 | Plumbagin |
| 32982 | SPEN | -0.60 | 7.0e-07 | 0.027 | Subtree 3 | Curcumin |
| 236613 | ACTN4P1 | 0.60 | 7.0e-07 | 0.027 | Subtree 3 | Plumbagin |
| 643769 | SMARCC1 | -0.65 | 7.0e-07 | 0.027 | Subtree 3 | O-Bromo-alpha-benzoyl cinnamonitrile |
| 643769 | RPSAP56 | -0.65 | 7.0e-07 | 0.027 | Subtree 3 | O-Bromo-alpha-benzoyl cinnamonitrile |
| 87868 | RPL10AP2 | -0.65 | 8.0e-07 | 0.027 | Subtree 3 | Phenethyl mustard oil |
| 87868 | HNRNPA1P64 | -0.65 | 8.0e-07 | 0.027 | Subtree 3 | Phenethyl mustard oil |
| 87868 | RPL34P18 | -0.65 | 8.0e-07 | 0.027 | Subtree 3 | Phenethyl mustard oil |
| 32982 | SRRM1 | -0.60 | 8.0e-07 | 0.027 | Subtree 3 | Curcumin |
| 643023 | FBXL2 | 0.66 | 8.0e-07 | 0.027 | Subtree 3 | Alpha-Phenyl-2,5-dimethoxy-alpha-cinnamonitrile |
| 742020 | RSL24D1 | -0.59 | 9.0e-07 | 0.027 | Subtree 3 | Ethoxycurcumin trithiadiazolaminomethylcarbonte |
| 236613 | G6PD | 0.59 | 9.0e-07 | 0.027 | Subtree 3 | Plumbagin |
| 87868 | HNRNPA1P55 | -0.65 | 1.0e-06 | 0.027 | Subtree 3 | Phenethyl mustard oil |
| 309909 | NPM3 | -0.60 | 1.0e-06 | 0.027 | Subtree 3 | Nimbolide |
| 742022 | PFN4 | 0.59 | 1.0e-06 | 0.027 | Subtree 3 | Curcumin tri trithiadiazolaminoethylcarbonate |
| 87868 | RPS4XP8 | -0.64 | 1.0e-06 | 0.027 | Subtree 3 | Phenethyl mustard oil |
| 87868 | RPS4XP1 | -0.64 | 1.2e-06 | 0.030 | Subtree 3 | Phenethyl mustard oil |
| 309909 | RPS10P5 | -0.59 | 1.2e-06 | 0.030 | Subtree 3 | Nimbolide |
| 643023 | ETNK2 | 0.65 | 1.4e-06 | 0.031 | Subtree 3 | Alpha-Phenyl-2,5-dimethoxy-alpha-cinnamonitrile |
| 742020 | HNRNPA1P4 | -0.59 | 1.4e-06 | 0.031 | Subtree 3 | Ethoxycurcumin trithiadiazolaminomethylcarbonte |
| 309909 | HNRNPA1L2 | -0.59 | 1.4e-06 | 0.031 | Subtree 3 | Nimbolide |
| 742019 | ITGAV | 0.59 | 1.4e-06 | 0.031 | Subtree 3 | Ethoxycurcumin tribenzimidazolmethylcarbonte |
| 742020 | RPL27AP | -0.58 | 1.4e-06 | 0.031 | Subtree 3 | Ethoxycurcumin trithiadiazolaminomethylcarbonte |
| 643769 | RPSA | -0.64 | 1.5e-06 | 0.032 | Subtree 3 | O-Bromo-alpha-benzoyl cinnamonitrile |
| 742019 | RPL21P44 | -0.58 | 1.5e-06 | 0.032 | Subtree 3 | Ethoxycurcumin tribenzimidazolmethylcarbonte |
| 236613 | SRXN1 | 0.58 | 1.7e-06 | 0.034 | Subtree 3 | Plumbagin |
| 365798 | TSKU | 0.64 | 1.8e-06 | 0.036 | Subtree 3 | Piceatannol |
| 705537 | SGF29 | 0.60 | 1.8e-06 | 0.036 | Subtree 3 | Daturaolone |
| 742022 | PDCD11 | -0.58 | 1.9e-06 | 0.036 | Subtree 3 | Curcumin tri trithiadiazolaminoethylcarbonate |
| 87868 | RPS4XP2 | -0.63 | 1.9e-06 | 0.036 | Subtree 3 | Phenethyl mustard oil |
| 32982 | HDAC10 | -0.58 | 1.9e-06 | 0.036 | Subtree 3 | Curcumin |
| 742020 | EEF1B2P1 | -0.58 | 2.0e-06 | 0.037 | Subtree 3 | Ethoxycurcumin trithiadiazolaminomethylcarbonte |
| 742019 | LINC00472 | 0.58 | 2.0e-06 | 0.037 | Subtree 3 | Ethoxycurcumin tribenzimidazolmethylcarbonte |
| 742021 | HMBOX1 | -0.58 | 2.2e-06 | 0.039 | Subtree 3 | Curcumin tri adamantylaminoethylcarbonate |
| 309909 | NOLC1 | -0.58 | 2.2e-06 | 0.039 | Subtree 3 | Nimbolide |
| 643023 | REEP3 | 0.64 | 2.3e-06 | 0.040 | Subtree 3 | Alpha.-Phenyl-2,5-dimethoxy-alpha-cinnamonitrile |
| 87868 | RPS4XP19 | -0.63 | 2.4e-06 | 0.040 | Subtree 3 | Phenethyl mustard oil |
| 32982 | NOC2L | -0.58 | 2.4e-06 | 0.041 | Subtree 3 | Curcumin |
| 309909 | RPL34P18 | -0.58 | 2.4e-06 | 0.041 | Subtree 3 | Nimbolide |
| 87868 | MYC | -0.63 | 2.6e-06 | 0.043 | Subtree 3 | Phenethyl mustard oil |
| 236613 | ALDH3A2 | 0.57 | 2.7e-06 | 0.043 | Subtree 3 | Plumbagin |
| 32982 | RCC2P4 | -0.58 | 2.7e-06 | 0.043 | Subtree 3 | Curcumin |
| 32982 | KHDRBS1 | -0.58 | 2.8e-06 | 0.043 | Subtree 3 | Curcumin |
| 32982 | DFFB | -0.58 | 2.8e-06 | 0.043 | Subtree 3 | Curcumin |
| 87868 | HNRNPA1P35 | -0.62 | 3.0e-06 | 0.043 | Subtree 3 | Phenethyl mustard oil |
| 643023 | CAPN2 | 0.63 | 3.0e-06 | 0.043 | Subtree 3 | Alpha.-Phenyl-2,5-dimethoxy-alpha-cinnamonitrile |
| 309909 | ANLN | 0.57 | 3.0e-06 | 0.043 | Subtree 3 | Nimbolide |
| 32982 | AHNAK2 | 0.57 | 3.1e-06 | 0.043 | Subtree 3 | Curcumin |
| 236613 | LOC344887 | 0.57 | 3.1e-06 | 0.043 | Subtree 3 | Plumbagin |
| 309909 | HNRNPA1P64 | -0.57 | 3.2e-06 | 0.043 | Subtree 3 | Nimbolide |
| 309909 | EIF4BP9 | -0.57 | 3.2e-06 | 0.043 | Subtree 3 | Nimbolide |
| 309909 | RPL29P7 | -0.57 | 3.2e-06 | 0.043 | Subtree 3 | Nimbolide |
| 742022 | LOC100128816 | -0.57 | 3.2e-06 | 0.043 | Subtree 3 | Curcumin tri trithiadiazolaminoethylcarbonate |
| 742022 | CUEDC1 | 0.57 | 3.3e-06 | 0.044 | Subtree 3 | Curcumin tri trithiadiazolaminoethylcarbonate |
| 32982 | CLIP4 | 0.57 | 3.3e-06 | 0.045 | Subtree 3 | Curcumin |
| 112166 | CRKL | 0.61 | 3.4e-06 | 0.045 | Subtree 3 | Cucurbitacin K |
| 236613 | PGRMC1 | 0.57 | 3.4e-06 | 0.045 | Subtree 3 | Plumbagin |
| 742019 | RPL21P12 | -0.57 | 3.5e-06 | 0.046 | Subtree 3 | Ethoxycurcumin tribenzimidazolmethylcarbonte |
| 32982 | ATAD3A | -0.57 | 3.7e-06 | 0.046 | Subtree 3 | Curcumin |
| 236613 | LRRC8A | 0.57 | 3.7e-06 | 0.046 | Subtree 3 | Plumbagin |
| 236613 | AFAP1 | 0.57 | 3.8e-06 | 0.046 | Subtree 3 | Plumbagin |
| 742022 | CAMSAP2 | 0.56 | 3.9e-06 | 0.046 | Subtree 3 | Curcumin tri trithiadiazolaminoethylcarbonate |
| 236613 | NEU3 | -0.56 | 3.9e-06 | 0.046 | Subtree 3 | Plumbagin |
| 742019 | RPS11P1 | -0.56 | 3.9e-06 | 0.046 | Subtree 3 | Ethoxycurcumin tribenzimidazolmethylcarbonte |
| 643023 | MT2P1 | 0.63 | 4.1e-06 | 0.046 | Subtree 3 | Alpha-Phenyl-2,5-dimethoxy-alpha-cinnamonitrile |
| 309909 | ACTN4P1 | 0.57 | 4.1e-06 | 0.046 | Subtree 3 | Nimbolide |
| 309909 | IKZF5 | -0.57 | 4.2e-06 | 0.046 | Subtree 3 | Nimbolide |
| 87868 | RPL34P31 | -0.61 | 4.2e-06 | 0.046 | Subtree 3 | Phenethyl mustard oil |
| 742019 | FIGN | 0.56 | 4.3e-06 | 0.046 | Subtree 3 | Ethoxycurcumin tribenzimidazolmethylcarbonte |
| 236613 | ELP2 | -0.56 | 4.4e-06 | 0.046 | Subtree 3 | Plumbagin |
| 309909 | HNRNPCP3 | -0.57 | 4.4e-06 | 0.046 | Subtree 3 | Nimbolide |
| 643769 | RPSAP47 | -0.61 | 4.4e-06 | 0.046 | Subtree 3 | O-Bromo-alpha-benzoyl cinnamonitrile |
| 309909 | MTPAP | -0.57 | 4.4e-06 | 0.046 | Subtree 3 | Nimbolide |
| 742020 | RPL21P120 | -0.56 | 4.5e-06 | 0.046 | Subtree 3 | Ethoxycurcumin trithiadiazolaminomethylcarbonte |
| 742022 | CRACR2A | -0.56 | 4.5e-06 | 0.046 | Subtree 3 | Curcumin tri trithiadiazolaminoethylcarbonate |
| 236613 | NQO1 | 0.56 | 4.5e-06 | 0.046 | Subtree 3 | Plumbagin |
| 643769 | RPS10 | -0.61 | 4.5e-06 | 0.046 | Subtree 3 | O-Bromo-alpha-benzoyl cinnamonitrile |
| 705537 | PDGFC | -0.58 | 4.6e-06 | 0.046 | Subtree 3 | Daturaolone |
| 742022 | DARS | -0.56 | 4.6e-06 | 0.046 | Subtree 3 | Curcumin tri trithiadiazolaminoethylcarbonate |
| 236613 | ANXA2P1 | 0.56 | 4.7e-06 | 0.046 | Subtree 3 | Plumbagin |
| 309909 | EIF4BP5 | -0.57 | 4.7e-06 | 0.046 | Subtree 3 | Nimbolide |
| 87868 | PDSS1 | -0.61 | 4.7e-06 | 0.046 | Subtree 3 | Phenethyl mustard oil |
| 309909 | RPL7AP12 | -0.56 | 4.8e-06 | 0.046 | Subtree 3 | Nimbolide |
| 383468 | RCC2P4 | -0.56 | 4.8e-06 | 0.046 | Subtree 3 | Andrographis Paniculata |
| 32982 | RASAL2 | 0.56 | 4.8e-06 | 0.046 | Subtree 3 | Curcumin |
| 309909 | RPL34P31 | -0.56 | 5.0e-06 | 0.047 | Subtree 3 | Nimbolide |
| 87868 | COL4A1 | 0.61 | 5.0e-06 | 0.047 | Subtree 3 | Phenethyl mustard oil |
| 309909 | SFXN2 | -0.56 | 5.0e-06 | 0.047 | Subtree 3 | Nimbolide |
| 643769 | HNRNPM | -0.61 | 5.2e-06 | 0.048 | Subtree 3 | O-Bromo-alpha-benzoyl cinnamonitrile |
| 87868 | PDGFD | 0.61 | 5.2e-06 | 0.048 | Subtree 3 | Phenethyl mustard oil |
| 87868 | RPL36AP39 | -0.61 | 5.2e-06 | 0.048 | Subtree 3 | Phenethyl mustard oil |
| 87868 | HNRNPA1P13 | -0.61 | 5.3e-06 | 0.048 | Subtree 3 | Phenethyl mustard oil |
| 309909 | SNORA14B | -0.56 | 5.3e-06 | 0.048 | Subtree 3 | Nimbolide |
| 87868 | BICC1 | 0.61 | 5.4e-06 | 0.048 | Subtree 3 | Phenethyl mustard oil |
| 87868 | PRSS23 | 0.61 | 5.4e-06 | 0.048 | Subtree 3 | Phenethyl mustard oil |
| 742022 | RPL6 | -0.56 | 5.5e-06 | 0.048 | Subtree 3 | curcumin tri trithiadiazolaminoethylcarbonate |
| 87868 | RPL34P6 | -0.61 | 5.5e-06 | 0.048 | Subtree 3 | Phenethyl mustard oil |
| 87868 | HNRNPA1P8 | -0.61 | 5.5e-06 | 0.048 | Subtree 3 | Phenethyl mustard oil |
| 309909 | TAF5 | -0.56 | 5.6e-06 | 0.048 | Subtree 3 | Nimbolide |
| 32982 | PRTG | 0.56 | 5.6e-06 | 0.048 | Subtree 3 | Curcumin |
| 643023 | ITGA3 | 0.62 | 5.7e-06 | 0.049 | Subtree 3 | Alpha.-Phenyl-2,5-dimethoxy-alpha-cinnamonitrile |
| 643769 | CTSD | 0.61 | 5.7e-06 | 0.049 | Subtree 3 | O-Bromo-alpha-benzoyl cinnamonitrile |
| 309909 | GALNT10 | 0.56 | 5.8e-06 | 0.049 | Subtree 3 | Nimbolide |
| 742020 | TFAP4 | -0.56 | 6.0e-06 | 0.050 | Subtree 3 | Ethoxycurcumin trithiadiazolaminomethylcarbonte |
| 309909 | RPL10AP2 | -0.56 | 6.0e-06 | 0.050 | Subtree 3 | Nimbolide |
Listed are the genes whose expression was associated with logGI50 of INPs with FDR adjusted p < 0.05. For each product, the subtree from hierarchical clustering shown in Fig. 1 is provided. The product of Ricinus communis (NSC 15384) was not included in the hierarchical clustering as its screening concentration units differed from all other INPs. ρ, Spearman correlation coefficient