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. 2022 May 7;15:52. doi: 10.1186/s13045-022-01272-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — LncRNA-PACERR expression in TAMs is activated in PDAC tissues and is associated with poor prognosis. A Schematic illustration of qRT-PCR forty-six sample preparation (n = 46). Tumour-associated macrophages (TAMs) from forty-six PDAC tissue samples were enriched with CD163 positive selection. M1 macrophages in normal tissue-resident macrophages (M1-NTRMs) from PDAC adjacent normal tissue samples of the same patient were enriched with CD80 positive selection. B Purity of CD163⁺ cells and CD80⁺ by CD163 and CD80 microbeads sorting. C Expression of LncRNA-PACERR in 46 pairs of TAMs and M1-NTRMs from PDAC. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. D Colocalization of LncRNA-PACERR (green) and CD163/CD80 (red) in 110 clinical samples of pancreatic ductal adenocarcinoma (PDAC) as shown by fluorescence microscopy. DAPI staining (blue) shows the nuclei (DNA). Scar bar: 50 μm. E Staining intensity of LncRNA-PACERR, CD163 and DAPI on the immunofluorescence from TMAs of 110 PDAC patients. Green represents LncRNA-PACERR. Red represents CD163. Blue represents DAPI. F Kaplan–Meier survival curve presenting the overall survival of 110 PDAC patients, grouped according to the extent of LncRNA-PACERR⁺ TAMs infiltration