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. 2022 May 7;286:121570. doi: 10.1016/j.biomaterials.2022.121570

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Fig. 1 — Comparison of DOG-IM4, DOG-IM2 and L319 LNPs characteristics.DOG-IM4, DOG-IM2 and L319 were synthesized (A) and combined with standard helper lipids for the preparation of mRNA-containing LNPs as described in Materials and Methods. The LNPs were characterized for pKa by TNS dye binding assay (B), particle size and surface charge by using a Zetasizer (Malvern instrument), and mRNA entrapment by Ribogreen accessibility assay (C). FI stands for fluorescence intensity, EE for encapsulation efficiency and PDI for polydispersity index.