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. 2022 May 7;286:121570. doi: 10.1016/j.biomaterials.2022.121570

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Fig. 3 — DOG-IM4 LNPs induce higher functional antibody titers than DOG-IM2 LNPs in immunogenicity studies with mice and are stable at 4°C.PanelA: Individual and mean hemagglutination inhibiting antibody titers (HI titers) measured in sera collected at D42 from Balb/c mice (n = 8) immunized at D0 and D21 with 10 μg of a monovalent A/California/07/2009 (H1N1) split influenza vaccine (Vaxigrip®; MIV) or with DOG-IM4, DOG-IM2 and L319 LNPs loaded with indicated amounts of mRNA encoding full-length hemagglutinin (HA) of closely related influenza virus strain A/Netherlands/602/2009 (H1N1). The vaccines in PBS were injected into the mouse quadriceps under a final volume of 50 μL. PanelB: Samples from the lot of DOG-IM4 LNPs used in (A) were retested after 6 and 12 months of storage in PBS under nitrogen at 4°C. Individual and mean HI titers are shown. The study comprised also a group of mice injected with MIV (10 μg Vaxigrip®) at each timepoint to confirm the consistency of HI titration test (not shown). NS = not statistically significant.