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. 2018 Jan 31;8(10):5473–5483. doi: 10.1039/c7ra13661g

Minimum inhibitory concentration (MIC) of the synthesized compounds against Gram positive and Gram negative bacteria.

Compounds Gram positivea Gram negativea
S. aureus B. cereus E. coli E. aerogenes S. typhimurium S. flexneri
4 33 ± 0.02 31 ± 0.25 28 ± 0.53 28 ± 0.29 32 ± 0.24 31 ± 0.27
5 42 ± 0.25 39 ± 0.21 26 ± 0.52 25 ± 0.51 26 ± 0.31 28 ± 0.85
6 32 ± 0.21 36 ± 0.37 24 ± 0.52 26 ± 0.44 25 ± 0.32 21 ± 0.54
7 34 ± 0.04 37 ± 0.12 23 ± 0.18 25 ± 0.56 23 ± 0.51 24 ± 0.15
8 31 ± 0.30 30 ± 0.56 25 ± 0.19 27 ± 0.65 25 ± 0.51 26 ± 0.61
9 30 ± 0.12 34 ± 0.18 18 ± 0.16 16 ± 0.54 18 ± 0.52 19 ± 0.32
10 32 ± 0.31 32 ± 0.49 17 ± 0.55 19 ± 0.65 19 ± 0.33 20 ± 0.52
11 32 ± 0.12 33 ± 0.14 23 ± 0.24 22 ± 0.13 22 ± 0.14 23 ± 0.24
12 40 ± 0.33 34 ± 0.85 19 ± 0.68 18 ± 0.61 20 ± 0.63 21 ± 0.46
13 35 ± 0.14 31 ± 0.56 26 ± 0.22 27 ± 0.24 26 ± 0.42 24 ± 0.64
14 30 ± 0.22 29 ± 0.43 24 ± 0.23 25 ± 0.32 27 ± 0.85 26 ± 0.73
15 31 ± 0.21 30 ± 0.72 16 ± 0.65 18 ± 0.43 18 ± 0.96 19 ± 0.35
16 36 ± 0.41 41 ± 0.11 17 ± 0.47 19 ± 0.52 17 ± 0.14 18 ± 0.82
17 22 ± 0.12 20 ± 0.45 16 ± 0.51 18 ± 0.42 19 ± 0.71 18 ± 0.18
18 21 ± 0.65 24 ± 0.31 18 ± 0.24 17 ± 0.66 19 ± 0.27 17 ± 0.52
19 37 ± 0.31 32 ± 0.51 25 ± 0.64 27 ± 0.44 28 ± 0.82 26 ± 0.61
20 24 ± 0.61 26 ± 0.52 18 ± 0.71 19 ± 0.52 16 ± 0.82 17 ± 0.42
21 28 ± 0.35 27 ± 0.63 25 ± 0.61 23 ± 0.51 27 ± 0.34 25 ± 0.34
22 34 ± 0.24 31 ± 0.11 20 ± 0.82 23 ± 0.15 20 ± 0.82 21 ± 0.58
23 33 ± 0.52 33 ± 0.41 21 ± 0.24 22 ± 0.61 23 ± 0.18 22 ± 0.31
24 35 ± 0.52 36 ± 0.16 29 ± 0.42 28 ± 0.52 27 ± 0.61 29 ± 0.51
25 22 ± 0.41 24 ± 0.52 15 ± 0.71 16 ± 0.42 18 ± 0.66 16 ± 0.82
26 20 ± 0.62 22 ± 0.42 16 ± 0.61 17 ± 0.15 16 ± 0.16 17 ± 0.18
27
28
29
30 35 ± 0.62 34 ± 0.65 27 ± 0.61 25 ± 0.81 27 ± 0.17 28 ± 0.61
31 36 ± 0.64 38 ± 0.62 26 ± 0.44 24 ± 0.19 24 ± 0.34 28 ± 0.11
32 30 ± 0.61 31 ± 0.32 25 ± 0.61 26 ± 0.61 29 ± 0.17 30 ± 0.15
33 28 ± 0.71 26 ± 0.55 19 ± 0.81 18 ± 0.34 19 ± 0.04 22 ± 0.07
34 38 ± 0.71 37 ± 0.53 30 ± 0.42 32 ± 0.13 28 ± 0.30 32 ± 0.17
35 30 ± 0.52 31 ± 0.35 28 ± 0.52 26 ± 0.77 29 ± 0.52 30 ± 0.10
36 26 ± 0.75 24 ± 0.43 18 ± 0.72 18 ± 0.55 17 ± 0.13 21 ± 0.53
A* 19 ± 0.24 18 ± 0.72 16 ± 0.14 16 ± 0.31 16 ± 0.42 19 ± 0.81
a

Values are mean of three determinations, the ranges of which are <5% of the mean in all cases. A*-standard ampicillin (−): not tested, (±) standard deviation.