Minimum inhibitory concentration (MIC) of the synthesized compounds against Gram positive and Gram negative bacteria.
Compounds | Gram positivea | Gram negativea | ||||
---|---|---|---|---|---|---|
S. aureus | B. cereus | E. coli | E. aerogenes | S. typhimurium | S. flexneri | |
4 | 33 ± 0.02 | 31 ± 0.25 | 28 ± 0.53 | 28 ± 0.29 | 32 ± 0.24 | 31 ± 0.27 |
5 | 42 ± 0.25 | 39 ± 0.21 | 26 ± 0.52 | 25 ± 0.51 | 26 ± 0.31 | 28 ± 0.85 |
6 | 32 ± 0.21 | 36 ± 0.37 | 24 ± 0.52 | 26 ± 0.44 | 25 ± 0.32 | 21 ± 0.54 |
7 | 34 ± 0.04 | 37 ± 0.12 | 23 ± 0.18 | 25 ± 0.56 | 23 ± 0.51 | 24 ± 0.15 |
8 | 31 ± 0.30 | 30 ± 0.56 | 25 ± 0.19 | 27 ± 0.65 | 25 ± 0.51 | 26 ± 0.61 |
9 | 30 ± 0.12 | 34 ± 0.18 | 18 ± 0.16 | 16 ± 0.54 | 18 ± 0.52 | 19 ± 0.32 |
10 | 32 ± 0.31 | 32 ± 0.49 | 17 ± 0.55 | 19 ± 0.65 | 19 ± 0.33 | 20 ± 0.52 |
11 | 32 ± 0.12 | 33 ± 0.14 | 23 ± 0.24 | 22 ± 0.13 | 22 ± 0.14 | 23 ± 0.24 |
12 | 40 ± 0.33 | 34 ± 0.85 | 19 ± 0.68 | 18 ± 0.61 | 20 ± 0.63 | 21 ± 0.46 |
13 | 35 ± 0.14 | 31 ± 0.56 | 26 ± 0.22 | 27 ± 0.24 | 26 ± 0.42 | 24 ± 0.64 |
14 | 30 ± 0.22 | 29 ± 0.43 | 24 ± 0.23 | 25 ± 0.32 | 27 ± 0.85 | 26 ± 0.73 |
15 | 31 ± 0.21 | 30 ± 0.72 | 16 ± 0.65 | 18 ± 0.43 | 18 ± 0.96 | 19 ± 0.35 |
16 | 36 ± 0.41 | 41 ± 0.11 | 17 ± 0.47 | 19 ± 0.52 | 17 ± 0.14 | 18 ± 0.82 |
17 | 22 ± 0.12 | 20 ± 0.45 | 16 ± 0.51 | 18 ± 0.42 | 19 ± 0.71 | 18 ± 0.18 |
18 | 21 ± 0.65 | 24 ± 0.31 | 18 ± 0.24 | 17 ± 0.66 | 19 ± 0.27 | 17 ± 0.52 |
19 | 37 ± 0.31 | 32 ± 0.51 | 25 ± 0.64 | 27 ± 0.44 | 28 ± 0.82 | 26 ± 0.61 |
20 | 24 ± 0.61 | 26 ± 0.52 | 18 ± 0.71 | 19 ± 0.52 | 16 ± 0.82 | 17 ± 0.42 |
21 | 28 ± 0.35 | 27 ± 0.63 | 25 ± 0.61 | 23 ± 0.51 | 27 ± 0.34 | 25 ± 0.34 |
22 | 34 ± 0.24 | 31 ± 0.11 | 20 ± 0.82 | 23 ± 0.15 | 20 ± 0.82 | 21 ± 0.58 |
23 | 33 ± 0.52 | 33 ± 0.41 | 21 ± 0.24 | 22 ± 0.61 | 23 ± 0.18 | 22 ± 0.31 |
24 | 35 ± 0.52 | 36 ± 0.16 | 29 ± 0.42 | 28 ± 0.52 | 27 ± 0.61 | 29 ± 0.51 |
25 | 22 ± 0.41 | 24 ± 0.52 | 15 ± 0.71 | 16 ± 0.42 | 18 ± 0.66 | 16 ± 0.82 |
26 | 20 ± 0.62 | 22 ± 0.42 | 16 ± 0.61 | 17 ± 0.15 | 16 ± 0.16 | 17 ± 0.18 |
27 | — | — | — | — | — | — |
28 | — | — | — | — | — | — |
29 | — | — | — | — | — | — |
30 | 35 ± 0.62 | 34 ± 0.65 | 27 ± 0.61 | 25 ± 0.81 | 27 ± 0.17 | 28 ± 0.61 |
31 | 36 ± 0.64 | 38 ± 0.62 | 26 ± 0.44 | 24 ± 0.19 | 24 ± 0.34 | 28 ± 0.11 |
32 | 30 ± 0.61 | 31 ± 0.32 | 25 ± 0.61 | 26 ± 0.61 | 29 ± 0.17 | 30 ± 0.15 |
33 | 28 ± 0.71 | 26 ± 0.55 | 19 ± 0.81 | 18 ± 0.34 | 19 ± 0.04 | 22 ± 0.07 |
34 | 38 ± 0.71 | 37 ± 0.53 | 30 ± 0.42 | 32 ± 0.13 | 28 ± 0.30 | 32 ± 0.17 |
35 | 30 ± 0.52 | 31 ± 0.35 | 28 ± 0.52 | 26 ± 0.77 | 29 ± 0.52 | 30 ± 0.10 |
36 | 26 ± 0.75 | 24 ± 0.43 | 18 ± 0.72 | 18 ± 0.55 | 17 ± 0.13 | 21 ± 0.53 |
A* | 19 ± 0.24 | 18 ± 0.72 | 16 ± 0.14 | 16 ± 0.31 | 16 ± 0.42 | 19 ± 0.81 |
Values are mean of three determinations, the ranges of which are <5% of the mean in all cases. A*-standard ampicillin (−): not tested, (±) standard deviation.