TABLE 2.

Initial Remission by Treatment

Variable	Remission* (%)	P †	Relapse (%)
Response to first treatment	47/115 (41)	-	5/47 (11)
Standard	47/114 (41)
Vigabatrin	10/52 (19)
ACTH	21/32 (66)		3‡/21 (14)
Prednisolone	16/30 (53)		2§/16 (13)
Nonstandard	0/1 (0)
Levetiracetam	0/1 (0)
Response to second treatment	25/62 (40)	0.004	4/25 (16)
Standard	23/44 (52)
Vigabatrin	10/22 (45)		2║/10 (20)
ACTH	3/5 (60)
Prednisolone	10/17 (59)		2¶/10 (20)
Nonstandard	2/18 (11)		0
Levetiracetam	0/1
Clobazam	1/9 (11)		0
Zonisamide	1/5 (20)		0
Topiramate	0/2
Oxcarbazepine	0/1
Response to third treatment	5/33 (15)	0.008	1/5 (20)
Standard	5/14 (36)
Vigabatrin	0/2 (0)
ACTH	2/5 (40)
Prednisolone	2/6 (33)		1#/2 (50)
Surgery	1/1 (100)
Nonstandard	0/19 (0)
Zonisamide	0/6
Clobazam	0/4
Ketogenic diet	0/4
Cannabidiol	0/3
Topiramate	0/2

Abbreviation:

ACTH = Adrenocorticotropic hormone

Values are N (row %)

^*Clinical remission beginning within two weeks of starting treatment and persisting for a minimum of 28 days plus electrographic remission.

^†Difference in remission between standard and nonstandard therapies tested using chi-square tests (Fisher’s exact test used if any group had fewer than five remissions).

^‡After relapse, remission by three months with epilepsy surgery (1), prednisolone (1), or vigabatrin (1).

^§Both with remission at three months but later relapsed without subsequent remission.

^║One with three-month remission and one without, both without subsequent remission.

^¶Both with remission at three months but later relapsed without subsequent remission.

^#Remission at three months but later relapse without subsequent remission.