a LS mean difference (ALIS–TIS) adjusted for treatment and randomisation strata at day 168 was −1.31% (95% CI −4.95 to 2.34; P = .48). The lower bound of the 95% CI was > −5%, indicating noninferiority of ALIS to TIS.
ALIS, amikacin liposome inhalation suspension; FEV1, forced expiratory volume in 1 second; LS, least squares; TIS, tobramycin inhalation solution.