Optimization of the azide–alkyne cycloaddition^a.

Entry	Catalyst	Mol%	Time (h)	Yieldb (%)	TONc (mol mol−1)	TOFd (h−1)
1	Cu( i )@pNIPAM-VP	5	2	94	18.8	9.4
2	Cu(i)@pNIPAM-VP	2	2	89	44.5	22.3
3	Cu(i)@pNIPAM-VP	1	2	62	62	31
4	Cu( ii )@pNIPAM-VP	1	2	91	91	45.5

^aReaction conditions: benzyl bromide (1.0 mmol), phenyl acetylene (1.0 mmol), sodium azide (1.0 mmol), H₂O (2 mL).

^bIsolated yield.

^cTON (turnover number): reactant moles converted/catalyst moles.

^dTOF (turnover frequency): TON/reaction time.