Fig. 9. Chemical structures of the designed compounds. Six template compounds (the top row of each box) representing four chemotypes (ethacrynic acid, benzyloxyacetic acid, phenoxyacetic acid and aromatic amide) served as chemical starting points for designing novel analogs (the bottom row of each box). Green circles represent the original moieties of the template compounds and pink circles represent the replacement moieties of the designed compounds.
