Fig. 5. Depletion of SNHG5 hindered tumor growth through facilitating miR-155 expression in vivo. Nude mice were injected with A375 cells stably transfected with sh-con or sh-SNHG5 to generate mice xenograft model of melanoma. After 7 days, mice inoculated with sh-SNHG5-transfected A375 cells were divided into two groups with one group mice was injected with miR-155 mimic every 7 days. (A) Tumor volume was detected using a caliper every 7 days. (B) Mice were sacrificed at 42 days after cell inoculation, and xenograft tumors were resected, photographed and weighted. (C) The expression patterns of miR-155 in excised tumor tissues. *P < 0.05.