TABLE 4.

In vitro susceptibilities to fluconazole of serial isolates of C. neoformans from 71 patients with cryptococcosis

Change in MIC	No. of patients
	1992 to 1994	1996 to 1998	Total
No change	17	16	33
Twofold change
Increase	15	10	25
Decrease	0	0	0
Fourfold change
Increase	3	1	4
Decrease	2	3	5
Eightfold change
Increase	0	2	2
Decrease	0	0	0
Greater than eightfold change
Increase	1	0	1
Decrease	0	1	1
Total	38	33	71