| Integrin-binding specificity regulates biomaterial surface chemistry effects on cell differentiation62
|
Gold-coated substrates |
CH3
|
7 and 14 days |
OH and NH2 upregulate osteoblast-specific gene expression compared with the COOH and CH3 substrates |
2005 |
| OH |
| COOH |
| NH2
|
| The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate69
|
Glass coverslips |
CH3
|
14 days onwards |
MSC phenotype unchanged |
2006 |
| NH2
|
Promoted and maintained osteogenesis |
| SH |
|
| OH |
Promoted and maintained chondrogenesis |
| COOH |
|
| Human mesenchymal stem cell differentiation on self-assembled monolayers presenting different surface chemistries65
|
Gold-coated substrates |
CH3
|
7, 10, 12 and 15 days (different experimental methods) |
Formation of 3D cell aggregates |
2010 |
| COOH |
Displayed a cobblestone phenotype typical of osteoblasts |
| NH2
|
Promoted osteogenic differentiation |
| OH |
Lower cell number |
| Directing the fate of human and mouse mesenchymal stem cells by hydroxyl-methyl mixed self-assembled monolayers with varying wettability94
|
Gold slides |
Mixed OH and CH3
|
7 days |
Promoted the expression of αvβ1 integrin of MSC |
2014 |
| Promoted osteogenic differentiation in the presence of biological stimuli |
| Effects of functional groups on the structure, physicochemical and biological properties of mesoporous bioactive glass scaffolds95
|
Mesoporous bioactive glass |
SH |
7 and 14 days |
Stimulated adhesion, proliferation and differentiation |
2015 |
| NH2
|
| Surface chemistry from wettability and charge for the control of mesenchymal stem cell fate through self-assembled monolayers96
|
Gold slides |
OEG |
7 and 14 days |
Not supported cell adhesion and proliferation |
2016 |
| CH3
|
| PO3H2
|
Promoted mouse MSC (mMSC) adhesion and proliferation |
| OH |
NH2 and PO3H2 promoted mMSC osteogenic differentiation |
| NH2
|
Upregulated the mMSC expression of integrins αv and β1
|
| COOH |
