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Effect of pbp4 inactivation on vancomycin susceptibility
| Strain | Vancomycin MIC
(μg/ml)a
|
|
|---|---|---|
| Broth microdilution | E-test | |
| RN450M | 2 | 2 |
| RN450MΔPBP4 | 2 | 3 |
| RN450MΔPBP4/pJF3b | 2 | 2 |
| N315 | 1 | 1 |
| N315ΔPBP4 | 1 | 3 |
| N315ΔPBP4/pJF3b | 1 | 1 |
| COL | 2 | 3 |
| COLΔPBP4 | 4.0 | 6 |
| COLΔPBP4/pJF3b | 2.0 | 3 |
MICs were determined by the broth microdilution and E-test methods as described in Materials and Methods.
MIC determination was done in the presence of chloramphenicol (5 μg/ml) to maintain pressure on pJF3.
