Scheme 10. Synthesis of arylnaphthalene lactone derivatives. Reagents and conditions: (a) LDA (3 equiv.) and THF, −78 °C to rt, 6–7 h, quenched with 3 M HCl; (b) MeI, K₂CO₃ and acetone, room temperature, 4–8 h; (c) crude product, K₂CO₃ and acetone, room temperature, 3 days.