Fig. 1. Multivariate analyses screening potential biomarkers. Principal component analysis score plots of the UPLC-MS data from patients (group 1) and controls (group 0) (A) and 3-D model (B). OPLS-DA of the UPLC-MS data from patients (group 1) and controls (group 0) (C) and 3-D model (D). VIP-plot of OPLS-DA for screening of differential metabolites (E).