Table 1.
Relationship between the number of CD4+T and CD8+T cells in peripheral blood and clinicopathological features in GC patients (M (P25 and P75)).
| Clinicopathological features | n (%) | CD4+T (cells/μl) | p | CD8+T (cells/μl) | p | CD4+T/CD8+T | p |
|---|---|---|---|---|---|---|---|
| Gender | |||||||
| Male | 63 (67.7) | 553.00 (430.00, 668.00) | 0.318 | 398.00 (301.00, 501.00) | 0.322 | 1.28 (1.09,1.64) | 0.115 |
| Female | 30 (32.3) | 572.50 (448.00, 748.50) | 387.50 (192.25, 487.25) | 1.44 (1.15, 2.42) | |||
| Age(years) | |||||||
| <60 | 56 (60.2) | 563.00 (340.25, 703.25) | 0.461 | 397.50 (228.25, 514.75) | 0.635 | 1.26 (1.12, 1.60) | 0.197 |
| ≥60 | 37 (39.8) | 560.00 (473.50, 676.00) | 399.00 (301.50, 480.00) | 1.36 (1.14, 2.33) | |||
| Histological type | |||||||
| Adenocarcinoma | 74 (79.6) | 572.50 (473.50, 727.75) | 0.056 | 403.50 (304.25, 493.25) | 0.446 | 1.33 (1.14, 1.75) | 0.584 |
| Signet-ring+mucinous adenocarcinoma | 19 (20.4) | 462.00 (364.00, 574.00) | 327.00 (264.00, 623.00) | 1.22 (0.98, 1.64) | |||
| Pathological type | |||||||
| Well differentiation | 28 (30.1) | 523.00 (330.5, 876.00) | 0.927 | 387.50 (305.5, 525.25) | 0.957 | 1.40 (1.14, 1.84) | 0.773 |
| Low differentiation | 65 (69.9) | 569.00 (448.00, 629.00) | 399.00 (264.00, 490.00) | 1.29 (1.13, 1.64) | |||
| Lauren classification | |||||||
| Intestinal type | 40 (43.0) | 635.50 (520.00, 828.25) | <0.001 | 452.50 (382.25, 544.75) | 0.007 | 1.39 (1.23, 1.60) | 0.091 |
| Mixed type | 24 (25.8) | 561.00 (340.25, 664.50) a | 348.50 (241.00, 479.75)a | 1.49 (1.08, 1.92) | |||
| Diffuse type | 29 (31.2) | 448.00 (281.00, 562.50) b | 328.00 (195.00, 469.50)b | 1.17 (0.78, 1.59) | |||
| Tumor location | |||||||
| Gastric cardia | 34 (36.5) | 572.50 (413.75, 650.25) | 0.730 | 412.50 (233.00, 495.00) | 0.669 | 1.39 (1.15, 1.75) | 0.839 |
| Gastric body | 22 (23.7) | 553.00 (458.50, 784.00) | 395.50 (304.00, 609.75) | 1.29 (1.14, 1.60) | |||
| Gastric antrum | 37 (39.8) | 560.00 (428.50, 686.00) | 398.00 (268.50, 485.50) | 1.29 (1.00, 1.88) | |||
| TNM stage | |||||||
| I~II | 45 (48.4) | 637.00 (490.00, 818.50) | 0.001 | 458.00 (327.50, 516.00) | 0.019 | 1.40 (1.17, 1.81) | 0.161 |
| III~IV | 48 (51.6) | 494.00 (372.00, 577.00) | 350.50 (211.00, 450.75) | 1.26 (1.01, 1.64) | |||
| Lymph node metastasis | |||||||
| Absent | 23 (24.7) | 664.00 (553.00, 736.00) | 0.002 | 488.00 (458.00, 558.00) | <0.001 | 1.26 (1.18, 1.59) | 0.824 |
| Present | 70 (75.3) | 506.50(359.75, 637.50) | 365.50 (226.75,448.25) | 1.33 (1.11, 1.90) | |||
| Nerve invasion | |||||||
| Absent | 63 (67.8) | 578.00 (487.00, 725.00) | 0.006 | 399.00 (326.00, 515.00) | 0.042 | 1.38 (1.14, 1.74) | 0.435 |
| Present | 30(32.2) | 472.00 (292.25, 585.50) | 338.50 (193.00, 484.00) | 1.22 (1.12, 1.71) | |||
| Vascular invasion | |||||||
| Absent | 51 (54.8) | 572.00 (483.00, 701.00) | 0.214 | 438.00 (341.00, 555.00) | 0.012 | 1.29 (1.12, 1.59) | 0.316 |
| Present | 42 (45.2) | 558.50 (334.75, 661.50) | 364.00 (221.25, 475.50) | 1.32 (1.14, 1.96) | |||
| Ki67 | |||||||
| ≤30% | 34 (36.6) | 607.50 (485.25, 701.75) | 0.239 | 442.50 (338.00,554.25) | 0.057 | 1.26 (1.11, 1.61) | 0.225 |
| >30% | 59 (63.4) | 529.00 (431.00, 694.00) | 395.00 (227.00,473.00) | 1.36 (1.14, 1.91) | |||
| NLR | |||||||
| High NLR | 47 (50.5) | 493.00 (308.00, 654.00) | 0.010 | 341.00 (207.00, 462.00) | 0.009 | 1.26 (0.78, 1.74) | 0.298 |
| Low NLR | 46 (49.5) | 586.00 (486.75, 709.25) | 449.50 (348.75, 518.50) | 1.34 (1.18, 1.67) | |||
| PLR | |||||||
| High PLR | 47 (50.5) | 557.00 (438.00, 668.00) | 0.875 | 399.00 (227.00, 494.00) | 0.684 | 1.33 (1.14, 1.74) | 0.642 |
| Low PLR | 46 (49.5) | 570.50 (436.75, 709.255) | 398.00 (301.75, 498.25) | 1.29 (1.05, 1.67) |
Note: NLR was peripheral blood neutrophil count/lymphocyte count; PLR was peripheral blood platelet count/lymphocyte count; taking the median NLR and PLR (1.96 vs. 117.24) as the cut-off value, 93 GC patients were categorized into high NLR group and low NLR group and high PLR group and low PLR group. Bold fonts are considered to have significant differences. aCorrelated with the intestinal type group p < 0.05; bcompared with the intestinal type group p < 0.01.