Optimization of the reaction conditions for the synthesis of dimethyl 2,2′-[(2Z,2′Z)-((1R,4R)-cyclohexane-1,4-diyl]bis(2-(benzylimino)-4-oxothiazolidin-3-yl-5-ylidene))(2Z,2′Z)-diacetate 5a.

Entry	Solvent	Temp. (°C)	Time (min)	Yield (%)
1	EtOH	23	7	84
2	MeOH	23	7	88
3	H2O	23	7	86
4	MeCN	23	7	65
5	DCM	23	7	60
6	Dioxane	23	7	46
7	DMF	23	7	55
8	—	23	10	67
9	H2O	50	7	75
10	H2O	70	7	63
11	H 2 O	23	10	88
12	H2O	23	25	89