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. 2018 Mar 14;8(19):10437–10445. doi: 10.1039/c8ra00728d

Cytotoxicity and NO inhibition activities of compounds 1–11a,b.

Compounds NO inhibition RAW 264.7 macrophages Cytotoxicity (HepG2)
3 5.79 ± 0.18 5.23 ± 0.12
4 23.90 ± 2.1 >50
6 6.93 ± 0.89 8.67 ± 1.02
7 20.54 ± 0.63 >50
L-NMMAc 41.88 ± 0.91
Doxorubicinc 1.04 ± 0.37
a

Values were expressed as the means ± SD based on three independent experiments.

b

Compounds 1,2,5,8–11 were inactive.

c

Positive controls.