Cytotoxicity and NO inhibition activities of compounds 1–11a,b.
| Compounds | NO inhibition RAW 264.7 macrophages | Cytotoxicity (HepG2) |
|---|---|---|
| 3 | 5.79 ± 0.18 | 5.23 ± 0.12 |
| 4 | 23.90 ± 2.1 | >50 |
| 6 | 6.93 ± 0.89 | 8.67 ± 1.02 |
| 7 | 20.54 ± 0.63 | >50 |
| L-NMMAc | 41.88 ± 0.91 | — |
| Doxorubicinc | — | 1.04 ± 0.37 |
Values were expressed as the means ± SD based on three independent experiments.
Compounds 1,2,5,8–11 were inactive.
Positive controls.