Pharmacokinetic parameters for compound 2d, 3n and 3o in SD rat following intravenous and oral administrationa.
| Parameters | 2d | 3n | 3o | |||
|---|---|---|---|---|---|---|
| IV | Oral | IV | Oral | IV | Oral | |
| Dose (mg kg−1) | 1 | 10 | 1 | 10 | 1 | 10 |
| Terminal T1/2 (h) | 0.78 | 0.93 | 10.40 | 5.01 | 10.69 | 9.86 |
| T max (h) | 0.08 | 0.50 | 0.50 | 2.00 | 0.58 | 2.00 |
| C max (ng mL−1) | 1057.10 | 494.83 | 2310.20 | 285.40 | 4179.64 | 8423.01 |
| AUC0–∞ (ng mL−1 h) | 421.60 | 498.60 | 12 670.46 | 1657.85 | 22 666.86 | 65 818.33 |
| V z (L kg−1) | 3.48 | — | 1.19 | — | 0.69 | — |
| Cl (L h−1 kg) | 3.39 | — | 0.08 | — | 0.05 | — |
| MRT0–∞ (h) | 0.44 | 1.86 | 12.71 | 6.55 | 12.36 | 12.58 |
| F (%) | — | 11.78 | — | 1.5 | — | 29.35 |
a
Values are the mean from three animals. Dash indicates that the value was not measured or was not relevant.