Figure 1.
Schematic diagram of the study design. (1) We collected data from the Psychiatric Genomics Consortium (PGC) and Adolescent Brain Cognitive Development (ABCD) database. The DTI template for white matter fiber tracts we used was from Atlas Track.49 (2) the polygenic risk scores for ADHD (PRSADHD) of 4673 children with European ancestry from the ABCD cohort were obtained based on the summary statistics of an independent ADHD GWAS study.4 Cross-sectionally bivariate associations were performed between PRSADHD, white matter microstructure, and behavioral assessments. The behaviors we mainly focused on in this study are the ADHD scale and screen time utilization (STU). (3) Longitudinal and mediation analyses were performed to explore integrative relationships between PRSADHD, white matter microstructure, the ADHD trait and STU. Potential confounding factors were regressed out in all the analyses (see Methods).