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. 2022 Mar 9;50(6):666–679. doi: 10.1007/s10439-022-02941-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Left column: mean values (± standard deviation) for the peak biomechanical responses over the cartilage–cartilage contact region in the X-ray- and MRI-based FE knee models (with varied templates) during the stance phase of the gait. (a) The maximum principal stress; (b) maximum principal strain; (c) fluid pressure; (d) fibril strain; and (e) minimum principal strain Statistical significances between the X-ray- and MRI-based models are shown based on the 1-D statistical parametric mapping. Right column: 95% confidence intervals (CI) for the difference (X-ray: MRI model) between the corresponding biomechanical response values during the stance phase of the gait.