Table 2.
Pairwise correlations among apathy and biomarkers in HIV+ participants.
| Variable | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. Apathy Composite | — | ||||||||||
| 2. Nadir CD4 (cells/µL) | .05 | — | |||||||||
| 3. Current CD4 (cells/µL) | .06 | .45** | — | ||||||||
| 4. Plasma RNA (% detectable) | .07 | .10 | .41* | — | |||||||
| 5. NFL (log10) | −.09 | −.02 | .13 | .08 | — | ||||||
| 6. pTau181 (log10) | .09 | −.10 | −.13 | .12 | −.06 | — | |||||
| 7. Kyn/Tryp Ratio (log10) | .01 | .02 | −.03 | .49* | .26** | .12 | — | ||||
| 8. Quinolinic Acid (log10) | −.07 | −.01 | −.07 | .14 | .12 | .03 | .21* | — | |||
| 9. BDNF (log10) | −.06 | .27** | .21* | .02 | .10 | .04 | .10 | −.11 | — | ||
| 10. TNF-α (log10) | .06 | .02 | −.01 | .36 | .19* | .11 | .24* | .41** | −.15 | — | |
| 11. GFAP (log10) | .10 | .15 | .02 | −.02 | .04 | .05 | .10 | .00 | −.05 | .02 | — |
Note. Apathy Composite is a sample-based z-score. CD4 = Cluster of Differentiation 4; RNA = Ribonucleic Acid; NFL = Neurofilament Light; pTau181 = phosphorylated Tau 181; Kyn/Tryp = Kynurenine/Tryptophan; BDNF = Brain-Derived Neurotrophic Factor; TNF-α = Tumor Necrosis Factor alpha. GFAP = Glial Fibrillary Acidic Protein.
*
p < .05
**
p < .01