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. Author manuscript; available in PMC: 2022 Oct 18.
Published in final edited form as: Pediatr Res. 2021 Nov 8;92(3):685–693. doi: 10.1038/s41390-021-01695-0

Figure 2:

Figure 2:

Airway (AW) responses to methacholine challenge in the in vitro living lung slice preparation from 21 day old male (A) and female (B) neonatal (P1–7) mice were pre-treated with or without CPAP for 7 days. Treatment groups consist of control (Ctrl, no CPAP, solid circles/lines) and 1 (open circle), 3 (grey circle), and 6 cmH2O (solid circle, dashed lines) CPAP. Values are expressed as fraction of baseline lumen size. The smaller lumen size at increasing concentration to methacholine signifies increased AW reactivity. *indicates significant difference in the slope of the response between Ctrl and CPAP animals (N=7–10 airways from 4–5 mice/group; *p<0.05 vs Ctrl).