Table 2.
Brain region specific accumulation and retention of NPs targeted with various peptides as measured using the permeability coefficient, Ktrans (min−1), with MRI. CC, corpus callosum; HC, hippocampus; CTX, cortex; HT, hypothalamus.
| NP Type | |||||||
|---|---|---|---|---|---|---|---|
| Control (x 10−4) | Cldn146-NP (x 10−4) | Cldn53-NP (x 10−4) | Ocldn207-NP (x 10−4) | C1C2-NP (x 10−4) | C1C2-NP (in 2-month-old mice) (x 10−4) | ||
| Brain Region | CC | 17±14 | 14±12 | 22±12 | 25±14 | 58±30 | 19±19 |
| HC | 18±12 | 12±5 | 18±85 | 19±14 | 40±30 | 19±17 | |
| CTX | 16±10 | 3±3 | 26±9 | 20±21 | 148±67 | 22±15 | |
| HT | 12±15 | 8±2 | 26±13 | 37±13 | 102±56 | 26±17 | |
| Muscle | 79±22 | 16±13 | 9±13 | 33±7 | 57±22 | 28±29 | |