Fig. 3. Effect of diabetes and 15 day administration of Met (500 mg kg−1), Trop1, Trop2 or Met + Trop1 on serum (a and b) and hippocampal (c and d) contents of insulin and 5-HT in rats. Statistical analysis was performed using one-way ANOVA, followed by Tukey's post hoc test (P < 0.05). Values are expressed as mean ± S.E of (6 rats) and a comparison was obtained for normal control (*), diabetic control (#), Met ($) and Trop1 treated (@) groups. Met: metformin (500 mg kg−1, p.o.); Trop1: tropisetron (1 mg kg−1, i.p); Trop2: tropisetron (2 mg kg−1, i.p).
