Substrate scope of 1 and synthesis of target molecules 3^a.

Entry	1 (R/R1)	2 (R2)	3	Yieldb (%)
1	1a (4-FC6H5/CH3)	2a (4-ClC6H5)	3a	66
2	1a (4-FC6H5/CH3)	2b (C6H5)	3b	58
3	1b (3-FC6H5/CH3)	2b (C6H5)	3c	62
4	1c (3-ClC6H5/CH3)	2a (4-ClC6H5)	3d	63
5	1c (3-ClC6H5/CH3)	2b (C6H5)	3e	68
6	1d (4-BrC6H5/CH3)	2a (4-ClC6H5)	3f	65
7	1d (4-BrC6H5/CH3)	2b (C6H5)	3g	62
8	1e (3-BrC6H5/CH3)	2b (C6H5)	3h	60
9	1f (C6H5/CH3)	2a (4-ClC6H5)	3i	65
10	1f (C6H5/CH3)	2b (C6H5)	3j	63
11	1f (C6H5/CH3)	2c (4-OCH3C6H5)	3k	64
12	1g (3-CH3C6H5/CH3)	2b (C6H5)	3l	62
13	1h (n-butyl/CH3)	2a (4-ClC6H5)	3m	70
14	1i (4-ClC6H5/H)	2a (4-ClC6H5)	3n	71
15	1j (3-ClC6H5/H)	2a (4-ClC6H5)	3o	72
16	1k (3-BrC6H5/H)	2c (4-OCH3C6H5)	3p	68
17	1l (4-CH3C6H5/H)	2a (4-ClC6H5)	3q	60
18	1a (4-FC6H5/CH3)	2d (n-propyl)	3r	62

^aThe reaction was performed with 1 (1.0 mmol), 2 (0.6 mmol), and p-TSA (0.3 mmol) in EtOH (15 mL) at reflux for 3 hours.

^bIsolated yields based on enaminones 1.