Fig. 2.

Mediation model example with amygdala subnuclei. Mediation model with amygdala subnuclei volume (Time 2) as an example of mediating the relationship with trauma exposure from the Trauma History Profile (Time 1) and concurrent internalizing, externalizing, and/or dysregulation symptoms measured via the CBCL (Time 2). Covariates included TIV for amygdala subnuclei volumes and age at the time of the structural MRI scans for all variables. Note that the amygdala and hippocampal subregions were modeled separately by hemisphere with either concurrent or change scores for CBCL for a total of 8 separate models (See Figs. S3–S6 in the Supplemental Materials for all models). Abbreviations: X = independent predictor variable; M = mediator variable(s); Y = dependent outcome variable; T1 = Time 1; T2 = Time 2.