Table 4.

All-Cause Mortality and Cardiovascular Events Hazard Ratios from Individual Papers, Demonstrating Results from Their Most Fully Adjusted Model

Study	Model	All-Cause Mortality	Cardiovascular Events	Model Adjusted for
Weir et al10	Adjusted RR	1.4 (1.1-1.8)	1.3 (0.9-2.0)	Matched patients from poorly dialyzable cohort to highly dialyzable cohort based on race, sex, and propensity scorea
Shireman et al6	Adjusted HR	0.84 (0.72-0.97)	0.86 (0.75-0.99)	Cardioselectivity, start of β-blocker, age, sex, race, BMI category, smoker status, substance use status, employment, inability of ambulate. Inability to transfer, diabetes, congestive heart failure, cerebrovascular accident, peripheral vascular disease, hemoglobin, self-care dialysis
Assimon et al7	Adjusted HR	0.93 (0.86-0.98)	0.85 (0.78-0.93)	Patient demographics, comorbid conditions, laboratory data, dialysis treatment parameters, and prescription medication use. Refer to Assimon et al7Table S2 for specifics
Wu et al8	Adjusted HR	0.82 (0.75-0.88)	0.89 (0.84-0.93)	Age, sex, comorbid conditions, concomitant medications

Note: All-cause mortality and cardiovascular events hazard ratios and relative risks for highly dialyzable β-blockers versus poorly dialyzable β-blockers across the 4 studies. The average adjusted ratio was calculated using Review Manager.

Abbreviations: BMI, body mass index; HR, hazard ratio; IRR, incidence rate ratio; RR, risk ratio.

^aWeir et al¹⁰ matched their dialyzability cohorts based on the characteristics above instead of adjusting for the said characteristics.