Skip to main content
. 2018 Mar 28;8(22):12069–12103. doi: 10.1039/c7ra13321a

Comparison of different conditions for the synthesis of products 41.

Entry Solvent Catalyst Temperature (°C) Time (h) Yield (%)
1 H2O PEG-200 r.t. 3 55–98 (ref. 54)
2 EtOH l-Proline r.t. 30–72 58–98 (ref. 55)
3 TBAF·3H2O 60 2 55–97 (ref. 56)
4 DCM Zn-salphen, DIPEA r.t. 6 13–60 (ref. 57)
5 PEG-400 Cu(OAc)2 70 15–40 48–98 (ref. 58)
6 H2O Cu(iii) 30 12–24 70–96 (ref. 59)