Comparison of different conditions for the synthesis of products 41.
Entry | Solvent | Catalyst | Temperature (°C) | Time (h) | Yield (%) |
---|---|---|---|---|---|
1 | H2O | PEG-200 | r.t. | 3 | 55–98 (ref. 54) |
2 | EtOH | l-Proline | r.t. | 30–72 | 58–98 (ref. 55) |
3 | — | TBAF·3H2O | 60 | 2 | 55–97 (ref. 56) |
4 | DCM | Zn-salphen, DIPEA | r.t. | 6 | 13–60 (ref. 57) |
5 | PEG-400 | Cu(OAc)2 | 70 | 15–40 | 48–98 (ref. 58) |
6 | H2O | Cu(iii) | 30 | 12–24 | 70–96 (ref. 59) |