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. 2018 Mar 28;8(22):12069–12103. doi: 10.1039/c7ra13321a

Comparison of different conditions for the synthesis of product 44.

Entry Solvent Catalyst Temperature (°C) Time (h) Yield (%)
1 Toluene (Fe(NO3)3·9H2O/TEMPO) r.t. 32–39 79–87 (ref. 62)
2 FHS 45 1–4 87–98 (ref. 63)
3 l-Proline r.t. 5–18 68–89 (ref. 65)
4 MeOH IRA-400 Cl resin r.t. 1.5–3 70–85 (ref. 66)
5 H2O PANI-HBF4 r.t. 30–50 min 88–97 (ref. 67)
6 MeOH 30 72 28–99 (ref. 68)