Comparison of different conditions for the synthesis of product 44.
Entry | Solvent | Catalyst | Temperature (°C) | Time (h) | Yield (%) |
---|---|---|---|---|---|
1 | Toluene | (Fe(NO3)3·9H2O/TEMPO) | r.t. | 32–39 | 79–87 (ref. 62) |
2 | — | FHS | 45 | 1–4 | 87–98 (ref. 63) |
3 | — | l-Proline | r.t. | 5–18 | 68–89 (ref. 65) |
4 | MeOH | IRA-400 Cl resin | r.t. | 1.5–3 | 70–85 (ref. 66) |
5 | H2O | PANI-HBF4 | r.t. | 30–50 min | 88–97 (ref. 67) |
6 | MeOH | — | 30 | 72 | 28–99 (ref. 68) |