TABLE 1.

Demographic and clinical characteristics of the 12 study patients

Patient	Age (yr)	Ht (cm)	Wt (kg)	Sexa	APACHE II scoreb	Principal diagnosis(es)	Infectious diagnosis	Isolated pathogen (MIC [μg/ml])	Outcome
1	55	166	71.0	F	30	End-stage liver disease	FUOc	None	Died
2	48	183	107.4	M	27	End-stage liver disease	Pneumonia	P. aeruginosa (4), Enterobacter cloacae (1)	Died
3	42	169	88.4	M	25	End-stage liver disease	Intra-abdominal sepsis	None	Survived
4	54	182	89.0	M	31	End-stage heart disease, sepsis	Pneumonia	None	Died
5	34	168	99.9	F	23	Idiopathic thrombocytopenia purpura, respiratory failure	Pneumonia	Klebsiella pneumoniae (1), Moraxella catarrhalis (0.03)	Survived
6	63	173	99.3	M	29	Congestive heart failure, cardiogenic shock	Pneumonia	Klebsiella oxytoca (0.125)	Survived
7	59	178	82.2	M	24	End-stage liver disease, sepsis	Intra-abdominal sepsis	Escherichia coli (0.03)	Died
8	41	178	133.8	M	32	Thoracic aortic dissection	Pneumonia	None	Survived
9	33	173	108.0	F	26	End-stage heart disease	FUO	None	Survived
10	70	204	125.3	F	29	Sepsis, rhabdomyolysis	Cellulitis	Group B streptococci (0.25)	Survived
11	73	172	136.0	M	28	Intra-abdominal sepsis	Intra-abdominal sepsis	None	Survived
12	52	170	82.8	M	29	Congestive heart failure, cardiogenic shock	Pneumonia	E. coli (0.06), Haemophilus influenzae (0.016)	Survived

^aF, female; M, male. 

^bAPACHE II score, Acute Physiology and Chronic Health Evaluation II score on admission to the intensive care unit. 

^cFUO, fever of unknown origin.