TABLE 5.
Calculated pharmacodynamic parameters for cefepime with various dosage regimens during CRRT
| Pharmacodynamic parameter | Parameter value by different dosage regimens and treatments
|
|||||||
|---|---|---|---|---|---|---|---|---|
| 1 g every 24 h
|
1 g every 12 h
|
2 g every 24 h
|
2 g every 12 h
|
|||||
| CVVH | CVVHDF (n = 2) | CVVH (n = 1) | CVVHDF (n = 1) | CVVH (n = 3) | CVVHDF (n = 4) | CVVH (n = 1) | CVVHDF | |
| T > MIC | NAa | NA | ||||||
| MIC ≤ 4 μg/ml | NA | 100% | 100% | 100% | 100% | 100% | 100% | NA |
| MIC = 8 μg/ml | NA | 74% | 100% | 100% | 100% | 100% | 100% | NA |
| MIC = 16 μg/ml | NA | 40% | 100% | 85% | 100% | 84% | 100% | NA |
| AUC0–24/MIC | ||||||||
| MIC ≤ 4 μg/ml | NA | 118 | 209 | 145 | 263 | 262 | 419 | NA |
| MIC = 8 μg/ml | NA | 59 | 104 | 73 | 131 | 131 | 210 | NA |
| MIC = 16 μg/ml | NA | 30 | 52 | 36 | 66 | 65 | 105 | NA |
a
NA, not available (dosage regimens not studied).