Table 3.

Multivariable Adjusted Hazard Ratios and 95% Confidence Intervals for the Association Between Multimorbidity Burden and Incident Heart Failure Among Adults Without and With HIV, Overall, and by Age, Sex, and Race/Ethnicity^a

Baseline charactersitics	PWoH			PWH			P valueb
Multimorbidity burden	0-1	2-3	≥4	0-1	2-3	≥4
Overall	1.0 (ref)	2.10 (1.92-2.29)	4.09 (3.64-4.61)	1.0 (ref)	1.33 (1.04-1.71)	2.41 (1.78-3.25)	<.001
Age group (y)
21-34	1.0 (ref)	1.93 (1.08-3.45)	8.10 (3.30-19.86)	1.0 (ref)	1.56 (0.63-3.87)	3.49 (0.69-17.56)	.46
35-54	1.0 (ref)	2.49 (2.22-2.79)	5.77 (4.86-6.85)	1.0 (ref)	1.25 (0.86-1.81)	2.74 (1.74-4.30)	<.001
55-64	1.0 (ref)	1.70 (1.45-1.98)	3.85 (3.20-4.65)	1.0 (ref)	1.44 (0.94-2.23)	2.70 (1.68-4.33)	.29
≥65	1.0 (ref)	1.45 (1.16-1.81)	2.43 (1.93-3.05)	1.0 (ref)	1.36 (0.66-2.78)	1.44 (0.69-2.97)	.35
Sex
Male	1.0 (ref)	2.12 (1.94-2.32)	4.08 (3.60-4.63)	1.0 (ref)	1.25 (0.96-1.65)	2.59 (1.89-3.55)	<.001
Female	1.0 (ref)	1.79 (1.36-2.35)	4.09 (2.90-5.78)	1.0 (ref)	1.65 (0.90-3.03)	1.30 (0.48-3.51)	.01
Race/ethnicity
White	1.0 (ref)	1.76 (1.55-1.99)	3.89 (3.29-4.59)	1.0 (ref)	1.29 (0.89-1.86)	3.17 (2.15-4.67)	.16
Black	1.0 (ref)	2.06 (1.78-2.39)	3.99 (3.26-4.88)	1.0 (ref)	1.40 (0.92-2.15)	1.44 (0.76-2.72)	.01
Hispanic	1.0 (ref)	3.22 (2.55-4.07)	6.02 (4.32-8.39)	1.0 (ref)	1.47 (0.65-3.33)	1.54 (0.53-4.47)	.11
Asian/Pacific Islander	1.0 (ref)	2.36 (1.29-4.33)	4.74 (2.02-11.09)	1.0 (ref)	0.67 (0.08-5.71)	16.39 (5.08-52.9)	.12
Other/unknown	1.0 (ref)	3.64 (2.54-5.22)	6.39 (3.41-11.95)	1.0 (ref)	1.34 (0.57-3.17)	—c	<.001

^aPWH, people with HIV; PWoH, people without HIV; ref, reference.

^bFor the joint hypothesis test that the associations of multimorbidity categories with incident heart failure are different among PWH and PWoH.

^cNo HF events observed.