Palladium-catalyzed one-pot two-step synthesis of unsymmetrical biaryl compounds^a.

^aReaction conditions: (a) 1m (1.1 equiv.), XPhos-Pd-G2 (1.0 mol%), XPhos (1.0 mol%), B₂pin₂ (1.2 equiv.), K₃PO₄·7H₂O (3.0 equiv.), EtOH (0.275 M), RT, 2 h; (b) second aryl chloride (1.0 equiv.),3.0 M aq. K₃PO₄·7H₂O (3.0 equiv.), RT. Isolated yield based on 1m.

^bXPhos-Pd-G2 (1.5 mol%) and XPhos (1.5 mol%).