Comparison of forward-order and reverse-order strategies in synthesis of unsymmetrical biaryl compounds^a.

Entry	Ar1–Cl	Ar2–Cl	Product	Forward yieldb (%)	Reverse yieldb (%)
1				87	98
2				84	25
3				65	93
4				91c	20
5				77c	42c
6				38d	79c
7				35c	85c

^aGeneral conditions: (a) first chloride (1.1 equiv.), XPhos-Pd-G2 (1.0 mol%), XPhos (1.0 mol%), B₂pin₂ (1.2 equiv.), K₃PO₄·7H₂O (3.0 equiv.), EtOH (0.275 M), RT, 2 h; (b) second chloride (1.0 equiv.), 3.0 M aq. K₃PO₄·7H₂O (3.0 equiv.), RT, 8 h.

^bYield of isolated product.

^c15 h for the second step.

^d6 h for the second step.