TABLE 1.
IC50s showing the intrinsic antimalarial activities of CQ and the putative chemosensitizers performed with the CQs and CQr strains of P. falciparum
| Compound | IC50 (μM)a
|
|
|---|---|---|
| D10 | RSA11 | |
| CQ | 0.027 ± 0.003 | 0.326 ± 0.013 |
| VPL | 12.72 ± 0.877 | 12.68 ± 1.272 |
| DES | 13.90 ± 0.007 | 11.74 ± 4.244 |
| TRF | 5.660 ± 1.045 | 5.901 ± 1.794 |
| PROG | 24.68 ± 4.612 | 23.77 ± 3.567 |
| CsA | 0.158 ± 0.019 | 0.275 ± 0.026 |
| IVM | 18.85 ± 4.730 | 8.898 ± 0.998 |
a
Values represent the means ± standard deviations for three independent experiments, each of which was performed in duplicate. The values obtained for each strain are not significantly different (P ≥ 0.05) between strains except for those for CQ, CsA, and IVM.