TABLE 2.

IC₅₀s of CQ alone and in combination with the chemosensitizers for CQ^s and CQ^r strains

Drug combinationa	IC50 (nM)b
	D10 (CQS)	RSA11 (CQR)
CQ	26.30 ± 2.963	337.4 ± 8.202
CQ + DES	24.56 ± 4.830	109.7 ± 0.141
CQ + TRF	25.82 ± 6.781	295.6 ± 33.94
CQ + VPL	22.79 ± 2.222	167.6 ± 62.73
CQ + DES-TRF	—c	69.84 ± 42.50
CQ + DES-VPL	—	36.08 ± 23.58
CQ + TRF-VPL	—	26.56 ± 21.49
CQ + DES-TRF-VPL	—	6.958 ± 4.005

^aThe concentrations of VPL, DES, and TRF were identical to those used in the radioactive chloroquine accumulation experiment whose results are shown in Fig. 2. 

^bValues are the means ± standard deviations for two independent experiments, each of which was performed in duplicate. 

^c—, These combinations were not tested for resistance reversal, as their individual components did not show any effect on the CQ^s strain.