Effective permeability (P_e), percentage of transport and membrane retention after 4 h in the PAMPA of PLG 1 and its fluorinated analogues 2 and 3^a.

Entry	Compound	P e (× 106)b cm s−1	Transport (%) (4 h)b	Membrane retentionb
1	1	ndc	ndc	ndc
2	(S,S)-2	2.68 ± 0.04	5.34 ± 0.08	50%
3	(R,S)-2	0.31 ± 0.03	0.65 ± 0.06	30%
4	(S,S,S)-3	ndc	ndc	ndc
5	(R,S,S)-3	ndc	ndc	ndc

^aData are expressed as the mean ± SD.

^bParameters definitions and their calculations are provided in Experimental section.

^cNot determined.