Synthesis of spirooxindole-pyrrolidine 4a–n.
Entry | 4a–n | Ar | Yield (%) |
---|---|---|---|
1 | 4a | C6H5 | 84 |
2 | 4b | p-MeC6H4 | 92 |
3 | 4c | p-ClC6H4 | 80 |
4 | 4d | 2,4-Cl2C6H3 | 74 |
5 | 4e | p-MeOC6H4 | 86 |
6 | 4f | p-BrC6H4 | 77 |
7 | 4g | p-FC6H4 | 84 |
8 | 4h | m-FC6H4 | 78 |
9 | 4i | m-MeC6H4 | 85 |
10 | 4j | m-BrC6H4 | 72 |
11 | 4k | p-CF3C6H4 | 76 |
12 | 4l | 2-Thiophene | 94 |
13 | 4m | 2-Furan | 89 |
14 | 4n | 3,4,5-Tri-MeOC6H2 | 69 |