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. 2018 Apr 17;8(26):14335–14346. doi: 10.1039/c8ra02358a

Synthesis of spirooxindole-pyrrolidine 4a–n.

graphic file with name c8ra02358a-u1.jpg
Entry 4a–n Ar Yield (%)
1 4a C6H5 84
2 4b p-MeC6H4 92
3 4c p-ClC6H4 80
4 4d 2,4-Cl2C6H3 74
5 4e p-MeOC6H4 86
6 4f p-BrC6H4 77
7 4g p-FC6H4 84
8 4h m-FC6H4 78
9 4i m-MeC6H4 85
10 4j m-BrC6H4 72
11 4k p-CF3C6H4 76
12 4l 2-Thiophene 94
13 4m 2-Furan 89
14 4n 3,4,5-Tri-MeOC6H2 69