The cytotoxic activity and selectivity of the synthesized compounds against a colorectal cancer cell line (HCT-116)a.
| Entry | 4a–n | HCT-116 (IC50, μM) | HCT-116 (IC50, μg ml−1) | VERO-B (IC50, μM) | SI* |
|---|---|---|---|---|---|
| 1 | 4a | ND | ND | ND | ND |
| 2 | 4b | 21 ± 2 | 9.7 | 26 | 1.2 |
| 3 | 4c | 20 ± 1.5 | 9.6 | 22 | 1.1 |
| 4 | 4d | 9 ± 0.6 | 4.6 | 9 | 1 |
| 5 | 4e | 26 ± 2 | 12.4 | 26 | 1 |
| 6 | 4f | 21 ± 1.3 | 11 | 30 | 1.4 |
| 7 | 4g | 16 ± 1 | 7.4 | 40 | 2.5 |
| 8 | 4h | 15 ± 1.4 | 7 | 18 | 1.2 |
| 9 | 4i | 7 ± 0.2 | 3.2 | 15 | 2.1 |
| 10 | 4j | 9 ± 0.5 | 4.7 | 20 | 2.2 |
| 11 | 4k | 9 ± 0.5 | 4.6 | 22 | 2.4 |
| 12 | 4l | 50 ± 3.5 | 22.7 | 60 | 1.2 |
| 13 | 4m | 29 ± 2 | 12.7 | 50 | 1.7 |
| 14 | 4n | 20 ± 1.25 | 11.1 | 40 | 2 |
| Positive control | Cisplatin | 12.6 ± 0.40 | 3.8 | 5 | 0.4 |
a
SI*: selectivity index, ND: not determine.