Fig. 7. Network of the identified potential biomarkers associated with MDR. The metabolites, genes, enzymes, and reactions are represented by a hexagon, ellipse, round rectangle, and diamond. The size of the node represents the direction of the change of metabolite in the MCF-7/ADR cells compared with the parental cells. The input compounds are filled with red. Node with centrality values (centroid and betweenness) greater than the threshold value is filled with dark blue. The potential biomarker with centrality values greater than the threshold value is shown in red border.