Figure 1.

Characteristics and sera neutralization of the Omicron sub-lineages

(A) Phylogenetic tree of the BA.1, BA.1.1, BA.2, and BA.3 sub-lineages. Fifty randomly selected sequences belonging to each of the Omicron sub-lineages from GISAID were used as query sequences.

(B) Prevalence of the Omicron sub-lineages and Delta variant based on all the sequences available on GISAID over the past 6 months.

(C) Spike mutations within the Omicron sub-lineages.

(D–G) Neutralization of pseudotyped WT (D614G) and Omicron sub-lineage viruses by sera collected from individuals vaccinated with two-dose BBIBP-CorV only (D), with a BBIBP-CorV homologous booster (E), or with a ZF001 heterologous booster dose (F) following two doses of BBIBP-CorV, or from individuals infected by Delta virus after vaccination (G). For all panels, values above the symbols denote geometric mean titer, and the numbers in parentheses denote the proportion of positive sera with ID₅₀ above the LOQ (dotted lines, >1:10). p values were determined by using a Wilcoxon matched-pairs signed-rank test (two-tailed).

See also Figures S1 and S2.