TABLE 4.

Structure-activity relationship (SAR) of analogs of RWJ-3981  

Compound name or no.	Substituent at position:		IC50 (μM)	LUMO energy (kcal/mol)
	R1	R2
RWJ-3981	Cl	Phenyl	0.2	−59.5
1	Cl	3,4-Dichlorinated phenyl	0.4	−63.6
2	Dimethylamino	Phenyl	22	−50.0
3	H	Phenyl	>25	−55.8
4	4-Methoxyanilino	Phenyl	>25	−50.7
5	2-Hydroxyethylthio	Phenyl	>25	−56.0
6	N-Morpholino	Phenyl	>25	−52.1