Fig. 6. PTEN was a target of miR-18a and miR-21. (A) Binding sites between PTEN and miR-18a. (B) Binding sites between PTEN and miR-21. (C and D) Luciferase reporter assay was performed in A549 cells. (E and F) The expression levels of PTEN in A549 cells transfected with miR-18a inhibitor, miR-21 inhibitor, miR-18a mimics, or miR-21 mimics. *p < 0.05, n = 3.
