Fig. 7. CASC2 regulated the PTEN/PI3K/Akt pathway by down-regulating miR-18a and miR-21. To investigate whether PTEN/PI3K/Akt pathway was involved in the effect of CASC2, A549 cells were co-transfected with pcDNA3.1-CASC2 and miR-18a/miR-21 mimics. The expression levels of PTEN, Akt, and p-Akt were detected by western blotting. *p < 0.05, n = 3.
