. 2022 May 8;17:36. doi: 10.1186/s13011-022-00467-1

Table 3.

Multivariate conditional logistic models on prevalence of health conditions (controlling for alcohol use disorders and tobacco use) odds ratios (95% confidence interval)

	Cannabis Use Disorder (CUD)-Documented vs Matched Controls	Cannabis Use (no disorder) (CU)-Documented vs Matched Controls	Cannabis Use Disorder (CUD)-Documented vs Cannabis Use (no disorder) (CU) -Documented
General Medical Conditions
Cancer	2.00 (1.43–2.80)^**	1.65 (1.44–1.88)^**	1.21 (0.85–1.73)
Diabetes Mellitus	1.95 (1.26–3.02)	1.23 (1.01–1.50)	1.58 (0.99–2.53)
Nervous System Disease	2.67 (2.06–3.47)^**	2.01 (1.81–2.24)^**	1.33 (1.01–1.75)
Sleep Disorders	3.70 (2.69–5.08)^**	2.38 (2.07–2.74)^**	1.55 (1.11–2.17)
Circulatory System Disease	2.04 (1.54–2.69)^**	1.69 (1.50–1.90)^**	1.20 (0.90–1.62)
Respiratory Disease	1.58 (1.24–2.00)^*	1.65 (1.49–1.83)^**	0.95 (0.74–1.23)
Digestive System Disease	2.08 (1.62–2.67)^**	2.03 (1.82–2.25)^**	1.03 (0.79–1.34)
Liver Disease	1.86 (1.20–2.90)^*	1.68 (1.37–2.06)^**	1.11 (0.69–1.78)
Musculoskeletal Disease	1.76 (1.36–2.26)^**	1.67 (1.51–1.85)^**	1.05 (0.80–1.37)
HIV/AIDS	7.88 (2.58–24.08)^*	1.18 (0.69–2.00)	6.70 (2.10–21.39)^**
Sexually Transmitted Disease Other Than HIV/AIDS	3.39 (1.81–6.36)^**	2.28 (1.68–3.08)^**	1.49 (0.75–2.94)
Mental Health Disorders	6.99 (5.03–9.70)^**	2.81 (2.51–3.15)^**	2.48 (1.76–3.51)^**
Substance Use Disorder (other than alcohol, cannabis, tobacco)	21.44 (9.43–48.73)^**	3.64 (2.53–5.25)^**	5.88 (2.43–14.22)^**
Conditions Known To Be Associated With Cannabis
Respiratory Disease	1.58 (1.24–2.00)^*	1.69 (1.05–2.73)	0.95 (0.74–1.23)
COPD	1.67 (1.23–2.27)	1.49 (1.30–1.71)^*	1.12 (0.81–1.55)
Chronic Obstructive Pulmonary Disease	2.51 (1.47–4.30)^*	1.57 (1.26–1.95)^**	1.61 (0.90–2.85)
Cancer	2.00 (1.43–2.80)^**	1.65 (1.44–1.88)^*	1.21 (0.85–1.73)
Ischemic Heart Disease	2.51 (1.47–4.30)^*	1.57 (1.26–1.95)^**	1.61 (0.90–2.85)
Obstructive Sleep Apnea	2.11 (1.27–3.50)^*	2.07 (1.64–2.62)^**	1.02 (0.59–1.75)
Multiple Sclerosis	6.09 (0.64–57.44)	3.14 (1.38–7.12)^*	1.94 (0.20–18.81)
HIV-AIDS	7.88 (2.58–24.08)^*	2.28 (1.68–3.08)^**	6.70 (2.10–21.39)^*
Tourette Syndrome	0 (0.00–1.00)	2.00 (0.18–22.06)	0 (0.00–1.00)
Testicular Cancer	2.11 (0.25–18.05)	0.70 (0.27–1.86)	3.00 (0.30–29.75)
Chronic Pain	1.85 (1.44–2.38)^**	1.74 (1.57–1.93)^**	1.06 (0.81–1.38)
Schizophrenia/Psychotic Disorder	5.98 (2.23–16.03)^*	1.69 (1.05–2.73)	3.53 (1.18–10.53)
Depression	7.01 (4.79–10.27)^**	2.46 (2.15–2.81)^**	2.85 (1.90–4.26)^**
Anxiety	5.99 (4.37–8.21)^**	2.74 (2.43–3.08)^**	2.19 (1.57–3.05)^**
Bipolar Disorder	6.49 (2.90–14.52)^**	2.54 (1.84–3.51)**	2.56 (1.07–6.09)
Social Anxiety Disorder	13.03 (2.18–77.94)^*	1.64 (0.85–3.17)	7.93 (1.24–50.59)
Post-Traumatic Stress Disorder	7.74 (2.66–22.51)^*	3.41 (1.99–5.83)^**	2.27 (0.73–7.13)
Substance Use Disorder (other than alcohol, cannabis, tobacco)	21.44 (9.43–48.73)^**	3.64 (2.53–5.25)^**	5.88 (2.43–14.22)^*

Cannabis Use Disorder (CUD)-Documented vs Matched Controls

Cannabis Use (no disorder) (CU)-Documented vs Matched Controls

Cannabis Use Disorder (CUD)-Documented vs Cannabis Use (no disorder) (CU) -Documented

General Medical Conditions

Cancer

2.00

(1.43–2.80)^**

1.65

(1.44–1.88)^**

1.21

(0.85–1.73)

Diabetes Mellitus

1.95

(1.26–3.02)

1.23

(1.01–1.50)

1.58

(0.99–2.53)

Nervous System Disease

2.67

(2.06–3.47)^**

2.01

(1.81–2.24)^**

1.33

(1.01–1.75)

Sleep Disorders

3.70

(2.69–5.08)^**

2.38

(2.07–2.74)^**

1.55

(1.11–2.17)

Circulatory System Disease

2.04

(1.54–2.69)^**

1.69

(1.50–1.90)^**

1.20

(0.90–1.62)

Respiratory Disease

1.58

(1.24–2.00)^*

1.65

(1.49–1.83)^**

0.95

(0.74–1.23)

Digestive System Disease

2.08

(1.62–2.67)^**

2.03

(1.82–2.25)^**

1.03

(0.79–1.34)

Liver Disease

1.86

(1.20–2.90)^*

1.68

(1.37–2.06)^**

1.11

(0.69–1.78)

Musculoskeletal Disease

1.76

(1.36–2.26)^**

1.67

(1.51–1.85)^**

1.05

(0.80–1.37)

HIV/AIDS

7.88

(2.58–24.08)^*

1.18

(0.69–2.00)

6.70

(2.10–21.39)^**

Sexually Transmitted Disease Other Than HIV/AIDS

3.39

(1.81–6.36)^**

2.28

(1.68–3.08)^**

1.49

(0.75–2.94)

Mental Health Disorders

6.99

(5.03–9.70)^**

2.81

(2.51–3.15)^**

2.48

(1.76–3.51)^**

Substance Use Disorder (other than alcohol, cannabis, tobacco)

21.44

(9.43–48.73)^**

3.64

(2.53–5.25)^**

5.88

(2.43–14.22)^**

Conditions Known To Be Associated With Cannabis

Respiratory Disease

1.58

(1.24–2.00)^*

1.69

(1.05–2.73)

0.95

(0.74–1.23)

COPD

1.67

(1.23–2.27)

1.49

(1.30–1.71)^*

1.12

(0.81–1.55)

Chronic Obstructive Pulmonary Disease

2.51

(1.47–4.30)^*

1.57

(1.26–1.95)^**

1.61

(0.90–2.85)

Cancer

2.00

(1.43–2.80)^**

1.65

(1.44–1.88)^*

1.21

(0.85–1.73)

Ischemic Heart Disease

2.51

(1.47–4.30)^*

1.57

(1.26–1.95)^**

1.61

(0.90–2.85)

Obstructive Sleep Apnea

2.11

(1.27–3.50)^*

2.07

(1.64–2.62)^**

1.02

(0.59–1.75)

Multiple Sclerosis

6.09

(0.64–57.44)

3.14

(1.38–7.12)^*

1.94

(0.20–18.81)

HIV-AIDS

7.88

(2.58–24.08)^*

2.28

(1.68–3.08)^**

6.70

(2.10–21.39)^*

Tourette Syndrome

(0.00–1.00)

2.00

(0.18–22.06)

(0.00–1.00)

Testicular Cancer

2.11

(0.25–18.05)

0.70

(0.27–1.86)

3.00

(0.30–29.75)

Chronic Pain

1.85

(1.44–2.38)^**

1.74

(1.57–1.93)^**

1.06

(0.81–1.38)

Schizophrenia/Psychotic Disorder

5.98

(2.23–16.03)^*

1.69

(1.05–2.73)

3.53

(1.18–10.53)

Depression

7.01

(4.79–10.27)^**

2.46

(2.15–2.81)^**

2.85

(1.90–4.26)^**

Anxiety

5.99

(4.37–8.21)^**

2.74

(2.43–3.08)^**

2.19

(1.57–3.05)^**

Bipolar Disorder

6.49

(2.90–14.52)^**

2.54

(1.84–3.51)**

2.56

(1.07–6.09)

Social Anxiety Disorder

13.03

(2.18–77.94)^*

1.64

(0.85–3.17)

7.93

(1.24–50.59)

Post-Traumatic Stress Disorder

7.74

(2.66–22.51)^*

3.41

(1.99–5.83)^**

2.27

(0.73–7.13)

Substance Use Disorder (other than alcohol, cannabis, tobacco)

21.44

(9.43–48.73)^**

3.64

(2.53–5.25)^**

5.88

(2.43–14.22)^*

^*P = < .01 ^**P = < .001