Inhibitory effect of compounds 1–16 on LPS-induced NO production in macrophagesa.
| Compounds | IC50 ± SDb (μM) | Compounds | IC50 ± SD (μM) |
|---|---|---|---|
| 1a | >100 | 8 | >100 |
| 1b | >100 | 9 | >100 |
| 2a | >100 | 10 | >100 |
| 2b | >100 | 11 | 53.91 ± 0.45 |
| 3a | >100 | 12 | 84.32 ± 0.72 |
| 3b | >100 | 13 | 33.15 ± 1.18 |
| 4 | 73.90 ± 0.24 | 14 | >100 |
| 5 | 73.13 ± 0.66 | 15 | 11.30 ± 0.87 |
| 6 | >100 | 16 | 52.09 ± 1.21 |
| 7 | >100 | Resveratrol | 40.20 ± 0.94 |
a
Resveratrol was used as positive control. Results are presented as the means ± SD (n = 3).
b
Concentration necessary for 50% inhibition (IC50).