Cytotoxicity of compounds 1–16 (IC50 in μM)a on A549 and K562 cells.
Compounds | A549 | K562 | Compounds | A549 | K562 |
---|---|---|---|---|---|
1a | – | – | 10 | – | – |
2a | – | – | 11 | 36.8 | 18.4 |
3a | – | – | 12 | 35.0 | 17.5 |
4 | 33.6 | 16.8 | 13 | – | 17.6 |
5 | 13.6 | 6.7 | 14 | – | 16.7 |
6 | 13.1 | 14.6 | 15 | 34.2 | 7.5 |
7 | – | 35.3 | 16 | – | 11.2 |
8 | – | – | Adriamycin | 2.9 | 2.0 |
9 | – | – |
Presents a pair of enantiomers; “–” presents IC50 values > 50 μM.