Significant altered metabolites induced by drugs that affect microtubule dynamics^a.

No.	RT/min	Biomarker	m/z	P value	AUC	FC	Trend	Metabolite pathway
1	35.704	DG(15 : 0/22 : 1(13Z)/0 : 0)	654.5905	**P < 0.01	0.674	1.298	↑	Glycerolipids metabolism
2	39.784	Myo-inositol 1-phosphate	261.0414	*P < 0.05	0.805	3.469	↑	Inositol phosphate metabolism
3	24.220	Cinnavalininate	301.0518	*P < 0.05	0.678	0.816	↓	Tryptophan catabolism
4	39.799	LysoPC (10 : 0)	413.3280	*P < 0.05	0.819	3.592	↑	Phospholipid metabolism
5	21.039	4-Aminobutyraldehyde	88.0743	*P < 0.05	0.546	1.628	↑	Arginine catabolism
6	11.865	Dimethylglycine	104.0729	*P < 0.05	0.561	0.620	↓	Glycine metabolism
7	15.049	l-Proline	116.0712	*P < 0.05	0.582	0.314	↓	Arginine and proline metabolism
8	15.609	Homocysteine	136.0404	**P < 0.01	0.655	1.632	↑	Cysteine and methionine metabolism
9	15.405	Dopamine	154.0883	*P < 0.05	0.606	1.440	↑	Tyrosine catabolism
10	13.764	l-Phenylalanine	165.9617	*P < 0.05	0.621	1.724	↑	Phenylalanine metabolism
11	12.077	L-Tryptophan	205.0541	*P < 0.05	0.547	2.195	↑	Tryptophan metabolite
12	17.052	d-Erythrose 4-phosphate	223.0174	**P < 0.01	0.501	0.644	↓	Pentose phosphate metabolism

^a“↑” indicates that the metabolite content in the drug-treated group is higher than that in the control group; “↓” indicates that the metabolite content in the drug-treated group is lower than that in the control group; the P value was calculated using One Way ANOVA with the Bonferroni correction (significance at *P < 0.05, **P < 0.01).