Significant altered metabolites induced by drugs that interfere with RNA^a.

No.	RT/min	Biomarker	m/z	P value	AUC	FC	Trend	Metabolite pathway
1	39.952	Ribonic acid	167.0589	***P < 0.001	0.520	1.562	↑	—
2	12.269	Deoxyadenosine	274.1097	***P < 0.001	0.875	1.646	↑	Purine metabolism
3	12.759	5-Thymidylic acid	340.2486	**P < 0.01	0.843	6.795	↑	Pyrimidine metabolism
4	40.002	Neryl glucoside	345.0645	**P < 0.01	0.807	0.004	↓	—
5	16.917	Uracil	113.0375	**P < 0.01	0.521	1.011	↑	Pyrimidine metabolism
6	0.675	Hypoxanthine	136.9216	***P < 0.001	0.821	2.487	↑	Pyrimidine metabolism
7	12.983	Isoleucine	131.9327	***P < 0.001	0.912	3.769	↑	Valine, leucine and isoleucine biosynthesis
8	19.790	Aspartic acid	134.0478	***P < 0.001	0.615	0.411	↓	Alanine, aspartate and glutamate metabolism
9	19.792	Dehydroalanine	88.0386	***P < 0.001	0.812	1.856	↑	Methylation metabolism
10	11.429	Dimethylglycine	104.0691	**P < 0.01	0.512	0.136	↓	Methylation metabolism
11	15.802	N-Methyl-d-aspartic acid	148.0639	**P < 0.01	0.735	0.021	↓	—
12	1.795	N-Acetyl-d-glucosamine 6-phosphate	319.0641	***P < 0.001	0.631	0.106	↓	Amino sugar and nucleotide sugar metabolism

^a“↑” indicates that the metabolite content in the drug-treated group is higher than that in the control group; “↓” indicates that the metabolite content in the drug-treated group is lower than that in the control group; the P value was calculated using One Way ANOVA with the Bonferroni correction (significance at *P < 0.05, **P < 0.01, ***P < 0.001); “—” means that there is no corresponding metabolite pathway determined by MetaboAnalyst 3.0.